ArticlePediatric research2011
Puberty is delayed in male mice with dextran sodium sulfate colitis out of proportion to changes in food intake, body weight, and serum levels of leptin.
Article in Pediatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Sex differences in resilience at puberty depend upon divergent effects of a stress steroid at α4βδ GABABrain research · 2025Article
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- Sexual differentiation of neural mechanisms of stress sensitivity during puberty.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Role of Leptin in the Digestive System.Frontiers in pharmacology · 2021Review
- Growth and Puberty in Children with Inflammatory Bowel Diseases.Biomedicines · 2020Review
- Prepubertal gonadectomy reveals sex differences in approach-avoidance behavior in adult mice.Hormones and behavior · 2020Article
- Developmental Aspects of Glucose and Calcium Availability on the Persistence of Memory Function Over the Lifespan.Frontiers in aging neuroscience · 2019Review
- Mice with infectious colitis exhibit linear growth failure and subsequent catch-up growth related to systemic inflammation and IGF-1.Nutrition research (New York, N.Y.) · 2017Article
- Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?Brain research · 2017Review
- Increases in Sex Hormones during Anti-Tumor Necrosis Factor α Therapy in Adolescents with Crohn's Disease.The Journal of pediatrics · 2016Observational
- Sex-specific regulation of weight and puberty by the Lin28/let-7 axis.The Journal of endocrinology · 2016Article
- Article
- Pathological fractures in paediatric patients with inflammatory bowel disease.European journal of pediatrics · 2014Review
- Endocrine therapy for growth retardation in paediatric inflammatory bowel disease.Paediatric drugs · 2014Review
- The emerging role of leptin antagonist as potential therapeutic option for inflammatory bowel disease.International reviews of immunology · 2014Review
- Delays in puberty, growth, and accrual of bone mineral density in pediatric Crohn's disease: despite temporal changes in disease severity, the need for monitoring remains.The Journal of pediatrics · 2013Review
- Partial normalization of pubertal timing in female mice with DSS colitis treated with anti-TNF-α antibody.Journal of gastroenterology · 2012Article
- Changes in inflammation and QoL after a single dose of infliximab during ongoing IBD treatment.Journal of pediatric gastroenterology and nutrition · 2012Article
- The use of ghrelin and ghrelin receptor agonists as a treatment for animal models of disease: efficacy and mechanism.Current pharmaceutical design · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In boys, inflammatory bowel disease often results in delayed puberty associated with decreased bone mineral density and decreased linear growth. Our goal was to investigate whether pubertal timing and levels of leptin differed between prepubertal male mice with colitis and food-restricted (FR) mice maintained at a similar weight. We induced colitis in 32-d-old male mice using dextran sodium sulfate (DSS), resulting in 10 d of worsening colitis. We followed up these mice for separation of the prepuce from the glans penis as a marker of pubertal progression. Compared with free-feeding control mice, DSS and FR mice had significantly lower weight on d 7-10 of treatment. DSS mice had later puberty than control and FR mice. DSS mice also had smaller testes, lower FSH levels, increased systemic cytokines, and increased colonic inflammation by histology. Leptin levels were similar between DSS and FR mice, whereas both had decreases in leptin compared with controls. We conclude that DSS colitis causes delayed puberty in sexually immature male mice beyond what is seen among FR mice of similar weight, food intake, and leptin levels. These experiments provide support for the hypothesis that pubertal delay in colitis is influenced by factors beyond poor weight gain alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.