ArticleJournal of dental research2010
Ethanol wet-bonding challenges current anti-degradation strategy.
Article in Journal of dental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Effect of 2% Chlorhexidine Following Acid Etching on Microtensile Bond Strength of Resin Restorations: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Mechanisms regulating the degradation of dentin matrices by endogenous dentin proteases and their role in dental adhesion. A review.American journal of dentistry · 2014Pooled it
- MMP Inhibitors on Dentin Stability: A Systematic Review and Meta-analysis.Journal of dental research · 2014Pooled it
- Immediate human pulp response to ethanol-wet bonding technique.Journal of dentistry · 2015Trial
- The critical barrier to progress in dentine bonding with the etch-and-rinse technique.Journal of dentistry · 2011Trial
- Effect of Bond Strength of Chitosan Containing Cavity Disinfectant on Deep or Superficial Dentin.Biomimetics (Basel, Switzerland) · 2026Article
- Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Gelatinolytic activity in dentin upon adhesive treatment.Scientific reports · 2024Article
- Long-term hybrid stability and matrix metalloproteinase inhibition by fucosterol in resin-dentin bonding biomechanics.Scientific reports · 2024Article
- Impact of Dentine Pretreatment with Matrix Metalloproteinase Inhibitors on Bond Strength of Coronal Composite Restorations: A Systematic Review and Meta-analysis of In Vitro Studies.European journal of dentistry · 2023Article
- Wet-bonding technique with ethanol may reduce protease activity in dentin-resin interface following application of universal adhesive system.Journal of clinical and experimental dentistry · 2023Article
- Evaluation of Chitosan-Oleuropein Nanoparticles on the Durability of Dentin Bonding.Drug design, development and therapy · 2023Article
- Distinct effects of polyphenols and solvents on dentin collagen crosslinking interactions and biostability.Dental materials : official publication of the Academy of Dental Materials · 2021Article
- Stability and remineralization of proteoglycan-infused dentin substrate.Dental materials : official publication of the Academy of Dental Materials · 2021Article
- Evaluation of Inhibitory Effect of Self-Etch Adhesives Incorporated with Proanthocyanidin on Cysteine Cathepsins Present in Dentin Hybrid Layer Using Gelatin Zymography: AnJournal of pharmacy & bioallied sciences · 2021Article
- MMP Inhibitors and Dentin Bonding: Systematic Review and Meta-Analysis.International journal of dentistry · 2021Review
- Effect of Remineralized Collagen on Dentin Bond Strength through Calcium Phosphate Ion Clusters or Metastable Calcium Phosphate Solution.Nanomaterials (Basel, Switzerland) · 2020Article
- Novel Orthodontic Cement Comprising Unique Imidazolium-Based Polymerizable Antibacterial Monomers.Journal of functional biomaterials · 2020Article
- Effect of thermo-mechanical cycling and chlorhexidine on the bond strength of universal adhesive system to dentin.Heliyon · 2020Article
- High-Performance Dental Adhesives Containing an Ether-Based Monomer.Journal of dental research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The long-term effectiveness of chlorhexidine as a matrix metalloproteinase (MMP) inhibitor may be compromised when water is incompletely removed during dentin bonding. This study challenged this anti-bond degradation strategy by testing the null hypothesis that wet-bonding with water or ethanol has no effect on the effectiveness of chlorhexidine in preventing hybrid layer degradation over an 18-month period. Acid-etched dentin was bonded under pulpal pressure simulation with Scotchbond MP and Single Bond 2, with water wet-bonding or with a hydrophobic adhesive with ethanol wet-bonding, with or without pre-treatment with chlorhexidine diacetate (CHD). Resin-dentin beams were prepared for bond strength and TEM evaluation after 24 hrs and after aging in artificial saliva for 9 and 18 mos. Bonds made to ethanol-saturated dentin did not change over time with preservation of hybrid layer integrity. Bonds made to CHD pre-treated acid-etched dentin with commercial adhesives with water wet-bonding were preserved after 9 mos but not after 18 mos, with severe hybrid layer degradation. The results led to rejection of the null hypothesis and highlight the concept of biomimetic water replacement from the collagen intrafibrillar compartments as the ultimate goal in extending the longevity of resin-dentin bonds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.