ArticleJournal of cell science2010
Wnt-dependent assembly of supermolecular Dishevelled-3-based complexes.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Novel Insights into the Role of Kras in Myeloid Differentiation: Engaging with Wnt/β-Catenin Signaling.Cells · 2023Review
- Regulation of Dishevelled DEP domain swapping by conserved phosphorylation sites.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Zooming in on the WNT/CTNNB1 Destruction Complex: Functional Mechanistic Details with Implications for Therapeutic Targeting.Handbook of experimental pharmacology · 2021Article
- Dickkopf-related protein 3 negatively regulates the osteogenic differentiation of rat dental follicle cells.Molecular medicine reports · 2017Article
- DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome.American journal of human genetics · 2016Article
- Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons.Molecular and cellular biology · 2013Article
- Dvl3 translocates IPMK to the cell membrane in response to Wnt.Cellular signalling · 2012Article
- Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin.Journal of molecular signaling · 2012Article
- Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.Journal of cell science · 2012Article
- Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Dishevelled3 is a novel arginine methyl transferase substrate.Scientific reports · 2012Article
- Dishevelled C-terminus: prolyl and histidinyl motifs.Acta physiologica (Oxford, England) · 2012Review
- Arginine methylation of G3BP1 in response to Wnt3a regulates β-catenin mRNA.Journal of cell science · 2011Article
- Probing the physical nature and composition of signalsomes.Journal of molecular signaling · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dishevelled-3 (Dvl3) is a multivalent scaffold protein that is essential to Wnt signaling during development. Although Dvl-based punctae have been visualized by fluorescence microscopy; the physical nature and dynamic character of the such complexes are enigmatic. We use steric-exclusion chromatography, affinity pull-downs, proteomics and fluorescence correlation microscopy to characterize supermolecular Dvl3-based complexes of totipotent mouse F9 cells. The molecular mass of the complexes ranges from that of homodimeric Dvl3 to well-defined peaks harboring supermolecular complexes of 0.4 to 2.0 MDa. Addition of Wnt3a stimulates the formation of Dvl3-based complexes of greater molecular mass within 30 minutes. The presence of DKK1 and knockdown of Dishevelled proteins block formation of the 2 MDa Dvl3-based complexes and also block Wnt3a stimulation of the canonical pathway. Fluorescent correlation microscopy identified supermolecular Dvl3-based complexes with a molecular mass >30 MDa in live cells; these complexes were provoked to form structures with even greater molecular mass by Wnt3a. We establish for the first time the physical and functional nature of very large, supermolecular Dvl3-based complexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.