ArticleDevelopment (Cambridge, England)2010
An anteroposterior wave of vascular inhibitor downregulation signals aortae fusion along the embryonic midline axis.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Sirenomelia: two case reports.Journal of medical case reports · 2021Article
- Duplication of the Inferior Vena Cava Associated with Open Spinal Dysraphism.Clinical neuroradiology · 2021Article
- Non-Invasive PPG-Based System for Continuous Heart Rate Monitoring of Incubated Avian Embryo.Sensors (Basel, Switzerland) · 2020Article
- Identification and fate mapping of the pancreatic mesenchyme.Developmental biology · 2018Article
- Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner.Developmental biology · 2015Article
- Avians as a model system of vascular development.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Quantitative imaging of cell dynamics in mouse embryos using light-sheet microscopy.Development (Cambridge, England) · 2014Article
- Dynamic responses of endothelial cells to changes in blood flow during vascular remodeling of the mouse yolk sac.Development (Cambridge, England) · 2013Article
- Notochordal cell-derived therapeutic strategies for discogenic back pain.Global spine journal · 2013Review
- VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus.Development (Cambridge, England) · 2013Article
- Signalling pathways that control vertebrate haematopoietic stem cell specification.Nature reviews. Immunology · 2013Review
- Arterial and venous progenitors of the major axial vessels originate at distinct locations.Developmental cell · 2013Article
- 'In parallel' interconnectivity of the dorsal longitudinal anastomotic vessels requires both VEGF signaling and circulatory flow.Journal of cell science · 2012Article
- VEGF-directed blood vessel patterning: from cells to organism.Cold Spring Harbor perspectives in medicine · 2012Review
- Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels.Circulation research · 2012Article
- Early arterial differentiation and patterning in the avian embryo model.Seminars in cell & developmental biology · 2011Review
- Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates.Seminars in cell & developmental biology · 2011Review
- A clinical and experimental overview of sirenomelia: insight into the mechanisms of congenital limb malformations.Disease models & mechanisms · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Paracrine signals, both positive and negative, regulate the positioning and remodeling of embryonic blood vessels. In the embryos of mammals and birds, the first major remodeling event is the fusion of bilateral dorsal aortae at the midline to form the dorsal aorta. Although the original bilaterality of the dorsal aortae occurs as the result of inhibitory factors (antagonists of BMP signaling) secreted from the midline by the notochord, it is unknown how fusion is later signaled. Here, we report that dorsal aortae fusion is tightly regulated by a change in signaling by the notochord along the anteroposterior axis. During aortae fusion, the notochord ceases to exert its negative influence on vessel formation. This is achieved by a transcriptional downregulation of negative regulators while positive regulators are maintained at pre-fusion levels. In particular, Chordin, the most abundant BMP antagonist expressed in the notochord prior to fusion, undergoes a dramatic downregulation in an anterior to posterior wave. With inhibitory signals diminished and sustained expression of the positive factors SHH and VEGF at the midline, fusion of the dorsal aortae is signaled. These results demonstrate a novel mechanism by which major modifications of the vascular pattern can occur through modulation of vascular inhibitors without changes in the levels of positive vascular regulators.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.