ArticleDevelopment (Cambridge, England)2010
Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster.Scientific reports · 2024Article
- A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification.Nature communications · 2024Article
- Adult and Larval Tracheal Systems Exhibit Different Molecular Architectures inInternational journal of molecular sciences · 2023Article
- Article
- Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling.Nature communications · 2022Article
- Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila.Nature cell biology · 2021Article
- Article
- A cell atlas of adult muscle precursors uncovers early events in fibre-type divergence in Drosophila.EMBO reports · 2020Article
- A hemipteran insect reveals new genetic mechanisms and evolutionary insights into tracheal system development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells.Journal of molecular cell biology · 2020Article
- A Functional Analysis of theG3 (Bethesda, Md.) · 2020Article
- A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death.Development (Cambridge, England) · 2019Article
- Development and Function of theGenetics · 2018Review
- The tracheal system in post-embryonic development of holometabolous insects: a case study using the mealworm beetle.Journal of anatomy · 2018Article
- Article
- Failure to Burrow and Tunnel Reveals Roles for jim lovell in the Growth and Endoreplication of the Drosophila Larval Tracheae.PloS one · 2016Article
- Multipotent versus differentiated cell fate selection in the developing Drosophila airways.eLife · 2015Article
- Article
- Progenitor outgrowth from the niche in Drosophila trachea is guided by FGF from decaying branches.Science (New York, N.Y.) · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adult structures in holometabolous insects such as Drosophila are generated by groups of imaginal cells dedicated to the formation of different organs. Imaginal cells are specified in the embryo and remain quiescent until the larval stages, when they proliferate and differentiate to form organs. The Drosophila tracheal system is extensively remodeled during metamorphosis by a small number of airway progenitors. Among these, the spiracular branch tracheoblasts are responsible for the generation of the pupal and adult abdominal airways. To understand the coordination of proliferation and differentiation during organogenesis of tubular organs, we analyzed the remodeling of Drosophila airways during metamorphosis. We show that the embryonic spiracular branch tracheoblasts are multipotent cells that express the homeobox transcription factor Cut, which is necessary for their survival and normal development. They give rise to three distinct cell populations at the end of larval development, which generate the adult tracheal tubes, the spiracle and the epidermis surrounding the spiracle. Our study establishes the series of events that lead to the formation of an adult tubular structure in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.