ArticleBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2011
Microchimerism in salivary glands after blood- and marrow-derived stem cell transplantation.
Article in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Salivary gland bioengineering - yesterday, today, tomorrow!Histology and histopathology · 2023Review
- Endothelial cell provenance: an unclear role in transplant medicine.Frontiers in transplantation · 2023Review
- Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications.Micromachines · 2020Review
- 3D Cell Culture of Human Salivary Glands Using Nature-Inspired Functional Biomaterials: The Egg Yolk Plasma and Egg White.Materials (Basel, Switzerland) · 2020Article
- Insight into Salivary Gland Aquaporins.Cells · 2020Review
- Sex differences in Sjögren's syndrome: a comprehensive review of immune mechanisms.Biology of sex differences · 2015Review
- Pre- and postmortem imaging of transplanted cells.International journal of nanomedicine · 2015Review
- Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion.International journal of oral science · 2014Article
- Neurotrophic factor GDNF promotes survival of salivary stem cells.The Journal of clinical investigation · 2014Article
- Quantitative analysis of protein and gene expression in salivary glands of Sjogren's-like disease NOD mice treated by bone marrow soup.PloS one · 2014Article
- Tumours and tissues: similar homeostatic systems?Targeted oncology · 2013Review
- Paracrine effects of bone marrow soup restore organ function, regeneration, and repair in salivary glands damaged by irradiation.PloS one · 2013Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
Blood- and marrow-derived stem cells (BMDSCs) provide disease-ameliorating effects for cardiovascular and autoimmune diseases. Microchimerism from donor BMDSCs has been reported in several recipient tissues. We hypothesized that this finding suggests a potential use of BMDSCs in the treatment of salivary dysfunctions. We investigated the presence of Y chromosome-positive cells in salivary gland biopsies of 5 females who had received a marrow or blood stem cell transplant from male donors. One to 16 years after transplantation, all recipients exhibited scattered Y chromosome-positive cells in the acini, ducts, and stroma of their salivary glands (mean of 1.01%). Potentially, these cells can be markers of transplantation tolerance, contribute to neoplastic epithelial tissues, or engraft at sites of injury. In addition, transplantation of BMDSCs could be used for treatment of Sjögren's syndrome and salivary glands damaged by therapeutic irradiation for cancers of the head and neck.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.