ArticleMalaria journal2010
The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settings.
Article in Malaria journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Seasonality of Plasmodium falciparum transmission: a systematic review.Malaria journal · 2015Pooled it
- Trial
- Trial
- Inter-relationships of cardinal features and outcomes of symptomatic pediatric Plasmodium falciparum MALARIA in 1,933 children in Kampala, Uganda.The American journal of tropical medicine and hygiene · 2013Trial
- Effects of malaria volunteer training on coverage and timeliness of diagnosis: a cluster randomized controlled trial in Myanmar.Malaria journal · 2012Trial
- Cerebral malaria in resource-limited African regions: Diagnostic and therapeutic challenges.Infectious medicine · 2026Review
- Estimating malaria attributable fraction using quantitative PCR in a longitudinal cohort in Eastern Uganda.medRxiv : the preprint server for health sciences · 2026Article
- Epidemiology, clinical spectrum, and outcomes of severe malaria in Eastern Uganda: a prospective study.Malaria journal · 2025Article
- Potential relationship between gut microbiota and animal diarrhea: a systematic review.Frontiers in microbiology · 2025Review
- Africa's public health battle with cerebral malaria: What are we up against?Qatar medical journal · 2024Article
- Effects of Climate Variability on Malaria Transmission in Southern Côte d'Ivoire, West Africa.International journal of environmental research and public health · 2023Article
- Estimating the burden of severe malarial anaemia and access to hospital care in East Africa.Nature communications · 2023Article
- Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso.Malaria journal · 2023Article
- Malaria hospitalisation in East Africa: age, phenotype and transmission intensity.BMC medicine · 2022Article
- Malaria infection and severe disease risks in Africa.Science (New York, N.Y.) · 2021Article
- Potential functions of atypical memory B cells in Plasmodium-exposed individuals.International journal for parasitology · 2020Review
- The clinical spectrum of severe childhood malaria in Eastern Uganda.Malaria journal · 2020Article
- Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study.PLoS medicine · 2020Article
- Clinical trials to assess adjuvant therapeutics for severe malaria.Malaria journal · 2020Article
- The age-specific incidence of hospitalized paediatric malaria in Uganda.BMC infectious diseases · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA greater understanding of the relationship between transmission intensity, seasonality and the age-pattern of malaria is needed to guide appropriate targeting of malaria interventions in different epidemiological settings.
methodsA systematic literature review identified studies which reported the age of paediatric hospital admissions with cerebral malaria (CM), severe malarial anaemia (SMA), or respiratory distress (RD). Study sites were categorized into a 3 × 2 matrix of Plasmodium falciparum transmission intensity and seasonality. Probability distributions were fitted by maximum likelihood methods, and best fitting models were used to estimate median ages and to represent graphically the age-pattern of each outcome for each transmission category in the matrix.
resultsA shift in the burden of CM towards younger age groups was seen with increasing intensity of transmission, but this was not the case for SMA or RD. Sites with 'no marked seasonality' showed more evidence of skewed age-patterns compared to areas of 'marked seasonality' for all three severe malaria syndromes.
conclusionsAlthough the peak age of CM will increase as transmission intensity decreases in Africa, more than 75% of all paediatric hospital admissions of severe malaria are likely to remain in under five year olds in most epidemiological settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.