ArticleBMC cell biology2010
LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity.
Article in BMC cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Genome-wide CRISPR screen identifies STK11 as a critical regulator of sialic acid clusters important for influenza A virus attachment.Journal of advanced research · 2026Article
- Truncated LKB1 nonenzymatically enhances Fas-induced apoptosis by acting as a surrogate of Smac.Cell death discovery · 2025Article
- Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy.Cancer research · 2023Article
- A protein interaction landscape of breast cancer.Science (New York, N.Y.) · 2021Article
- Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex.Developmental biology · 2017Article
- Coordinated cell motility is regulated by a combination of LKB1 farnesylation and kinase activity.Scientific reports · 2017Article
- Review
- LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.Molecular biology of the cell · 2016Article
- Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers.Oncotarget · 2016Article
- Competition between human cells by entosis.Cell research · 2014Article
- Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.The Journal of clinical investigation · 2014Article
- Expression and transcriptional profiling of the LKB1 tumor suppressor in cervical cancer cells.Gynecologic oncology · 2014Article
- Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation.The Journal of cell biology · 2014Article
- A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.Nature cell biology · 2014Article
- LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.Molecular and cellular biology · 2013Article
- LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.The Journal of biological chemistry · 2013Article
- Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice.Histochemistry and cell biology · 2013Article
- Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis.The Journal of cell biology · 2012Article
- The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.PloS one · 2012Article
- Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGermline mutations in LKB1 result in Peutz-Jeghers Syndrome characterized by intestinal hamartomas and increased incidence of epithelial cancers. LKB1 encodes a serine/threonine kinase that plays an important role in regulating energy metabolism through the AMPK/mTOR signaling pathway. In addition, LKB1 is homologous to PAR-4, a polarity protein first described in C. elegans, while activation of LKB1 in mammalian epithelial cells induces the polarized assembly of actin filaments.
resultsTo explore the mechanism by which LKB1 interacts with the actin cytoskeleton, we introduced LKB1 into HeLa cells that lack endogenous LKB1. This results in activation of the small GTPase Rho and the assembly of linear actin filaments associated with focal adhesions. These effects on the actin cytoskeleton are attenuated by siRNA-mediated depletion of the guanine nucleotide exchange factor Dbl. Co-expression of the LKB1 with the adaptor protein STRAD induces actin filament puncta associated with phospho-ezrin.
conclusionsThis study reveals that LKB1 regulates the actin cytoskeleton through a Dbl/Rho pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.