ArticleBMC medical genetics2010
Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe).
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization.Journal of advanced research · 2023Article
- Significant association ofJournal of diabetes and metabolic disorders · 2021Article
- Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study.Scientific reports · 2021Article
- Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study.Scientific reports · 2021Article
- Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy.Journal of diabetes research · 2021Review
- Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population.Electronic physician · 2018Article
- Review
- Emerging role of liver X receptors in cardiac pathophysiology and heart failure.Basic research in cardiology · 2016Review
- Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans.Arthritis research & therapy · 2014Article
- Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes.International journal of endocrinology · 2014Review
- Association of liver X receptors (LXRs) genetic variants to gallbladder cancer susceptibility.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- LXR is a negative regulator of glucose uptake in human adipocytes.Diabetologia · 2013Article
- Liver X Receptors and female reproduction: when cholesterol meets fertility!Journal of endocrinological investigation · 2013Review
- Molecular Interactions between NAFLD and Xenobiotic Metabolism.Frontiers in genetics · 2013Article
- Liver X receptors and fat cell metabolism.International journal of obesity (2005) · 2012Review
- Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR.Nature reviews. Molecular cell biology · 2012Review
- A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia.BMC medical genetics · 2011Article
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Authors and funding
21 authors at 12 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe liver X receptors (LXR) α and β regulate lipid and carbohydrate homeostasis and inflammation. Lxrβ⁻/⁻ mice are glucose intolerant and at the same time lean. We aimed to assess the associations between single nucleotide polymorphisms (SNPs) in LXRβ and risk of type 2 diabetes mellitus (T2DM), obesity and related traits in 3 separate cohort studies.
methodsTwenty LXRβ SNPs were identified by sequencing and genotyped in the HUNT2 adult nested case-control study for T2DM (n = 835 cases/1986 controls). Five tag-SNPs (rs17373080, rs2695121, rs56151148, rs2303044 and rs3219281), covering 99.3% of the entire common genetic variability of the LXRβ gene were identified and genotyped in the French MONICA adult study (n = 2318) and the European adolescent HELENA cross-sectional study (n = 1144). In silico and in vitro functionality studies were performed.
resultsWe identified suggestive or significant associations between rs17373080 and the risk of (i) T2DM in HUNT2 (OR = 0.82, p = 0.03), (ii) obesity in MONICA (OR = 1.26, p = 0.05) and (iii) overweight/obesity in HELENA (OR = 1.59, p = 0.002). An intron 4 SNP (rs28514894, a perfect proxy for rs17373080) could potentially create binding sites for hepatic nuclear factor 4 alpha (HNF4α) and nuclear factor 1 (NF1). The C allele of rs28514894 was associated with ~1.25-fold higher human LXRβ basal promoter activity in vitro. However, no differences between alleles in terms of DNA binding and reporter gene transactivation by HNF4α or NF1 were observed.
conclusionsOur results suggest that rs17373080 in LXRβ is associated with T2DM and obesity, maybe via altered LXRβ expression.
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