ArticleBehavioral neuroscience2010
Normal maternal behavior, but increased pup mortality, in conditional oxytocin receptor knockout females.
Article in Behavioral neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03211013 (Placebo-Controlled Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Placebo-Controlled Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis.PloS one · 2015Pooled it
- Oxytocin agonist TGOT differentially modulates synaptic plasticity and intrinsic excitability in a sex-specific manner in the juvenile rat hippocampus.Communications biology · 2026Article
- Cell Type-Specific Hormonal Signaling Configures Hypothalamic Circuits for Parenting.bioRxiv : the preprint server for biology · 2025Article
- Sex-dimorphic oxytocin regulation of CA1-dependent spatial memory and synaptic plasticity in juvenile rats.Behavioral and brain functions : BBF · 2025Article
- Failure in the mother-young communication in domestic mammals: endocrine and behavioral aspects.Frontiers in veterinary science · 2025Review
- Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny.Scientific reports · 2024Article
- Oxytocin receptors in the nucleus accumbens shell are necessary for the onset of maternal behavior.Frontiers in neuroscience · 2024Article
- Distinct roles of amylin and oxytocin signaling in intrafamilial social behaviors at the medial preoptic area of common marmosets.Communications biology · 2023Article
- Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neural basis for behavioral plasticity during the parental life-stage transition in mice.Frontiers in neural circuits · 2023Review
- Oxytocin-a social peptide? Deconstructing the evidence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish.International journal of molecular sciences · 2022Review
- Parental Behavior in Rodents.Advances in neurobiology · 2022Article
- Oxytocin in Women's Health and Disease.Frontiers in endocrinology · 2022Review
- Article
- Oxytocin receptor disruption in Avil-expressing cells results in blunted sociability and increased inter-male aggression.PloS one · 2021Article
- Impaired experience-dependent maternal care in presynaptic active zone protein CAST-deficient dams.Scientific reports · 2020Article
- Neonatal Tactile Stimulations Affect Genetic Generalized Epilepsy and Comorbid Depression-Like Behaviors.Frontiers in behavioral neuroscience · 2020Article
- Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.PloS one · 2019Article
- Sex-Related Differences in Plasma Oxytocin Levels in Humans.Clinical practice and epidemiology in mental health : CP & EMH · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Oxytocin (Oxt) and the Oxt receptor (Oxtr) are implicated in the onset of maternal behavior in a variety of species. Recently, we developed two Oxtr knockout lines: a total body knockout (Oxtr-/-) and a conditional Oxtr knockout (OxtrFB/FB) in which the Oxtr is lacking only in regions of the forebrain, allowing knockout females to potentially nurse and care for their biological offspring. In the current study, we assessed maternal behavior of postpartum OxtrFB/FB females toward their own pups and maternal behavior of virgin Oxtr-/- females toward foster pups and compared knockouts of both lines to wildtype (Oxtr+/+) littermates. We found that both Oxtr-/- and OxtrFB/FB females appear to have largely normal maternal behaviors. However, with first litters, approximately 40% of the OxtrFB/FB knockout dams experienced high pup mortality, compared to fewer than 10% of the Oxtr+/+ dams. We then went on to test whether or not this phenotype occurred in subsequent litters or when the dams were exposed to an environmental disturbance. We found that regardless of the degree of external disturbance, OxtrFB/FB females lost more pups on their first and second litters compared to wildtype females. Possible reasons for higher pup mortality in OxtrFB/FB females are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.