ArticleJournal of proteome research2010
Proteomic analysis of human nail plate.
Article in Journal of proteome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages.Journal of developmental biology · 2025Article
- Pangolin scales as adaptations for innate immunity against pathogens.BMC biology · 2024Article
- Environmental pro-oxidants induce altered envelope protein profiles in human keratinocytes.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- VISTA and its ligands: the next generation of promising therapeutic targets in immunotherapy.Cancer cell international · 2023Review
- Protein profiling of forehead epidermal corneocytes distinguishes frontal fibrosing from androgenetic alopecia.PloS one · 2023Article
- V-Set and immunoglobulin domain containing (VSIG) proteins as emerging immune checkpoint targets for cancer immunotherapy.Frontiers in immunology · 2022Review
- Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development.PloS one · 2022Article
- Identification of two novel mutations in theMolecular medicine reports · 2021Article
- Predictive Model of Nail Consistency Using Scanning Electron Microscopy with Energy-Dispersive X-Ray.Biology · 2021Article
- Assessment of Absorption of Glycated Nail Proteins in Patients with Diabetes Mellitus and Diabetic Retinopathy.Medicina (Kaunas, Lithuania) · 2020Article
- Ubiquitously Expressed Proteins and Restricted Phenotypes: Exploring Cell-Specific Sensitivities to Impaired tRNA Charging.Trends in genetics : TIG · 2020Review
- Immunolocalization and phylogenetic profiling of the feather protein with the highest cysteine content.Protoplasma · 2019Article
- Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.Antimicrobial agents and chemotherapy · 2019Article
- Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton.Apoptosis : an international journal on programmed cell death · 2019Article
- Corneocyte proteomics: Applications to skin biology and dermatology.Experimental dermatology · 2018Review
- Mutation in Phospholipase C, δ1 (Balkan journal of medical genetics : BJMG · 2018Article
- Proteomic profiling of Pachyonychia congenita plantar callus.Journal of proteomics · 2017Article
- Available sustainable alternatives replace endangered animal horn based on their proteomic analysis and bio-effect evaluation.Scientific reports · 2016Article
- Effects of water on fingernail electron paramagnetic resonance dosimetry.Journal of radiation research · 2016Article
- High-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures.Plant biotechnology journal · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Shotgun proteomic analysis of the human nail plate identified 144 proteins in samples from Causcasian volunteers. The 30 identified proteins solubilized by detergent and reducing agent, 90% of the total nail plate mass, were primarily keratins and keratin associated proteins. Keratins comprised a majority of the detergent-insoluble fraction as well, but numerous cytoplasmic, membrane, and junctional proteins and histones were also identified, indicating broad use by transglutaminases of available proteins as substrates for cross-linking. Two novel membrane proteins were identified, also found in the hair shaft, for which mRNAs were detected only at very low levels by real-time polymerase chain reaction in other tissues. Parallel analyses of nail samples from volunteers from Inner Mongolia, China gave essentially the same protein profiles. Comparison of the profiles of nail plate and hair shaft from the latter volunteers revealed extensive overlap of protein constituents. Analyses of samples from an arsenic-exposed population revealed few proteins whose levels were altered substantially but raised the possibility of detecting sensitive individuals in this way.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.