ArticleProteins2010
Computational modeling of laminin N-terminal domains using sparse distance constraints from disulfide bonds and chemical cross-linking.
Article in Proteins, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Accounting for Neighboring Residue Hydrophobicity in Diethylpyrocarbonate Labeling Mass Spectrometry Improves Rosetta Protein Structure Prediction.Journal of the American Society for Mass Spectrometry · 2022Article
- A cross-linking/mass spectrometry workflow based on MS-cleavable cross-linkers and the MeroX software for studying protein structures and protein-protein interactions.Nature protocols · 2018Article
- A Novel MS-Cleavable Azo Cross-Linker for Peptide Structure Analysis by Free Radical Initiated Peptide Sequencing (FRIPS).Journal of the American Society for Mass Spectrometry · 2017Article
- Novel Concepts of MS-Cleavable Cross-linkers for Improved Peptide Structure Analysis.Journal of the American Society for Mass Spectrometry · 2017Article
- Monitoring Solution Structures of Peroxisome Proliferator-Activated Receptor β/δ upon Ligand Binding.PloS one · 2016Article
- Protein structure prediction guided by crosslinking restraints--A systematic evaluation of the impact of the crosslinking spacer length.Methods (San Diego, Calif.) · 2015Article
- Automated assignment of MS/MS cleavable cross-links in protein 3D-structure analysis.Journal of the American Society for Mass Spectrometry · 2015Article
- Article
- Structural analysis of guanylyl cyclase-activating protein-2 (GCAP-2) homodimer by stable isotope-labeling, chemical cross-linking, and mass spectrometry.Journal of the American Society for Mass Spectrometry · 2013Article
- Article
- Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry.Molecular & cellular proteomics : MCP · 2012Article
- BCL::Fold--de novo prediction of complex and large protein topologies by assembly of secondary structure elements.PloS one · 2012Article
- StavroX--a software for analyzing crosslinked products in protein interaction studies.Journal of the American Society for Mass Spectrometry · 2012Article
- BCL::Score--knowledge based energy potentials for ranking protein models represented by idealized secondary structure elements.PloS one · 2012Article
- Crystal structures of the network-forming short-arm tips of the laminin β1 and γ1 chains.PloS one · 2012Article
- Crystal structure of the ligand binding domain of netrin G2.Journal of molecular biology · 2011Article
- Determinants of laminin polymerization revealed by the structure of the α5 chain amino-terminal region.EMBO reports · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Basement membranes are thin extracellular protein layers, which separate endothelial and epithelial cells from the underlying connecting tissue. The main noncollagenous components of basement membranes are laminins, trimeric glycoproteins, which form polymeric networks by interactions of their N-terminal (LN) domains; however, no high-resolution structure of laminin LN domains exists so far. To construct models for laminin β(1) and γ(1) LN domains, 14 potentially suited template structures were determined using fold recognition methods. For each target/template-combination comparative models were created with Rosetta. Final models were selected based on their agreement with experimentally obtained distance constraints from natural cross-links, that is, disulfide bonds as well as chemical cross-links obtained from reactions with two amine-reactive cross-linkers. We predict that laminin β(1) and γ(1) LN domains share the galactose-binding domain-like fold.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.