ArticleMagnetic resonance in medicine2011
Further studies on the anisotropic distribution of collagen in articular cartilage by μMRI.
Article in Magnetic resonance in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Orientation-Independent T2 Mapping Enhances MRI-Based Cartilage Characterization.Annals of biomedical engineering · 2025Article
- The interface region between articular cartilage and bone by μMRI and PLM at microscopic resolutions.Microscopy research and technique · 2022Article
- Characterization complex collagen fiber architecture in knee joint using high-resolution diffusion imaging.Magnetic resonance in medicine · 2020Article
- Quantitative µMRI and PLM study of rabbit humeral and femoral head cartilage at sub-10 µm resolutions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Orientation anisotropy of quantitative MRI relaxation parameters in ordered tissue.Scientific reports · 2017Article
- Discrimination of healthy and osteoarthritic articular cartilage by Fourier transform infrared imaging and Fisher's discriminant analysis.Biomedical optics express · 2016Article
- Inhomogeneous Response of Articular Cartilage: A Three-Dimensional Multiphasic Heterogeneous Study.PloS one · 2016Article
- Effect of partial H2O-D2O replacement on the anisotropy of transverse proton spin relaxation in bovine articular cartilage.PloS one · 2014Article
- Experimental issues in the measurement of multi-component relaxation times in articular cartilage by microscopic MRI.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013Article
- Effects of unloading on knee articular cartilage T1rho and T2 magnetic resonance imaging relaxation times: a case series.The Journal of orthopaedic and sports physical therapy · 2012Article
- Anisotropic properties of bovine nasal cartilage.Microscopy research and technique · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To further study the anisotropic distribution of the collagen matrix in articular cartilage, microscopic magnetic resonance imaging experiments were carried out on articular cartilages from the central load-bearing area of three canine humeral heads at 13 μm resolution across the depth of tissue. Quantitative T2 images were acquired when the tissue blocks were rotated, relative to B0, along two orthogonal directions, both perpendicular to the normal axis of the articular surface. The T2 relaxation rate (R2) was modeled, by three fibril structural configurations (solid cone, funnel, and fan), to represent the anisotropy of the collagen fibrils in cartilage from the articular surface to the cartilage/bone interface. A set of complex and depth-dependent characteristics of collagen distribution was found in articular cartilage. In particular, there were two anisotropic components in the superficial zone and an asymmetrical component in the radial zone of cartilage. A complex model of the three-dimensional fibril architecture in articular cartilage is proposed, which has a leaf-like or layer-like structure in the radial zone, arises in a radial manner from the subchondral bone, spreads and arches passing the isotropic transitional zone, and exhibits two distinct anisotropic components (vertical and transverse) in the surface portion of the tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.