Trial reportEuropean journal of nutrition2011
Effects of a diet with inulin-enriched pasta on gut peptides and gastric emptying rates in healthy young volunteers.
Trial report in European journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01244945 (Effect of Lactobacillus Reuteri DSM 17938 on Gut Motility in Patients With Functional Constipation), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Lactobacillus Reuteri DSM 17938 on Gut Motility in Patients With Functional Constipation
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Effect of prebiotics, probiotics, and synbiotics on gastrointestinal outcomes in healthy adults and active adults at rest and in response to exercise-A systematic literature review.Frontiers in nutrition · 2022Pooled it
- Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review.Systematic reviews · 2021Pooled it
- Estimating Inulin Intake and Its Contribution to Total Fibre Intake in UK School-Aged Children: A Pilot Feasibility Study.Nutrition bulletin · 2025Article
- Microbiota and enteric nervous system crosstalk in diabetic gastroenteropathy: bridging mechanistic insights to microbiome-based therapies.Frontiers in cellular and infection microbiology · 2025Review
- Interleukin-10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study.JPEN. Journal of parenteral and enteral nutrition · 2020Article
- Prebiotics Inhibit Proteolysis by Gut Bacteria in a Host Diet-Dependent Manner: a Three-Stage ContinuousApplied and environmental microbiology · 2020Article
- Survival of L. casei DGEuropean journal of nutrition · 2019Article
- Update on gastrointestinal radiopharmaceuticals and dosimetry estimates.Seminars in nuclear medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOur group has previously shown that the administration of pasta enriched along with the prebiotic inulin induces a significant reduction in triglyceride and glucose levels with a significant delay in gastric emptying (GE) rates. This protective effect may occur by affecting the release of a number of gut peptides involved in the control of gastrointestinal motility. The aim of the present study was to evaluate the effects of inulin-enriched pasta on the circulating levels of neurotensin (NT), somatostatin (SS), and corticotropin-releasing factor (CRF) in relation to the GE time in young healthy subjects.
methodsTwenty healthy young male volunteers completed a randomized double-blind crossover study consisting of a 2-week run-in period and two 5-week study periods (11% inulin-enriched/control pasta), with an 8-week wash-out period in between. Gut peptide concentrations were evaluated by radioimmunoassay. GE time was evaluated by ultrasonography.
resultsThe prebiotic treatment significantly increased the area under the curve (AUC) values of both NT and SS (p < 0.05 Dunn's post-test). With regard to gastric motility, along with a significant delay in both the final time and T (1/2) gastric emptying time, a positive correlation was found between T (1/2) and SS AUC values (r = 0.57, p = 0.009) in the inulin-enriched pasta group.
conclusionThese results support the hypothesis that inulin plays an active role in mechanisms affecting the release of these gut peptides, which may modulate the gastric emptying of digesta.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.