ReviewPsychopharmacology2011
Brain serotonin receptors and transporters: initiation vs. termination of escalated aggression.
Review in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed.
- Assessment of Probiotics' Impact on Neurodevelopmental and Behavioral Responses in Zebrafish Models: Implications for Autism Spectrum Disorder Therapy.Probiotics and antimicrobial proteins · 2025Article
- High Resolution Postmortem MRI Discovers Developing Structural Connectivity in the Human Ascending Arousal Network.Human brain mapping · 2025Article
- Study on the Correlation Between Aggressive Behavior and Gut Microbiota and Serum Serotonin (5-HT) in Working Dogs.Veterinary sciences · 2025Article
- Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement.Diseases (Basel, Switzerland) · 2024Article
- Exploring the influence of stress on aggressive behavior and sexual function: Role of neuromodulator pathways and epigenetics.Heliyon · 2024Review
- Serotonin drives aggression and social behaviors of laboratory male mice in a semi-natural environment.Frontiers in behavioral neuroscience · 2024Article
- Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1).International journal of molecular sciences · 2022Article
- Altered Expression of Genes Associated with Major Neurotransmitter Systems in the Reward-Related Brain Regions of Mice with Positive Fighting Experience.International journal of molecular sciences · 2022Article
- Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression.Molecular psychiatry · 2022Article
- Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.Nature communications · 2021Article
- Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus).Hormones and behavior · 2021Article
- 17-α-Ethinylestradiol modulates endocrine and behavioral responses to stress in zebrafish.Environmental science and pollution research international · 2020Article
- Sex-dependent effects of social isolation on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT) and serotonin (5HT) 1a receptor binding and aggression.Hormones and behavior · 2019Article
- Parental Psychological Control and Adolescent Aggressive Behavior: Deviant Peer Affiliation as a Mediator and School Connectedness as a Moderator.Frontiers in psychology · 2019Article
- RGS2 drives male aggression in mice via the serotonergic system.Communications biology · 2019Article
- Sex differences in aggression: Differential roles of 5-HT2, neuropeptide F and tachykinin.PloS one · 2019Article
- Central serotonin modulates neural responses to virtual violent actions in emotion regulation networks.Brain structure & function · 2018Article
- Mechanisms Underlying Aggressive Behavior Induced by Antiepileptic Drugs: Focus on Topiramate, Levetiracetam, and Perampanel.Behavioural neurology · 2018Review
- Differential Roles of the Two Raphe Nuclei in Amiable Social Behavior and Aggression - An Optogenetic Study.Frontiers in behavioral neuroscience · 2018Article
- Effect of Group Density on the Physiology and Aggressive Behavior of Male Brandt's Voles (Zoological studies · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
rationaleRecent findings have shown a complexly regulated 5-HT system as it is linked to different kinds of aggression.
objectiveWe focus on (1) phasic and tonic changes of 5-HT and (2) state and trait of aggression, and emphasize the different receptor subtypes, their role in specific brain regions, feed-back regulation and modulation by other amines, acids and peptides.
resultsNew pharmacological tools differentiate the first three 5-HT receptor families and their modulation by GABA, glutamate and CRF. Activation of 5-HT(1A), 5-HT(1B) and 5-HT(2A/2C) receptors in mesocorticolimbic areas, reduce species-typical and other aggressive behaviors. In contrast, agonists at 5-HT(1A) and 5-HT(1B) receptors in the medial prefrontal cortex or septal area can increase aggressive behavior under specific conditions. Activation of serotonin transporters reduce mainly pathological aggression. Genetic analyses of aggressive individuals have identified several molecules that affect the 5-HT system directly (e.g., Tph2, 5-HT(1B), 5-HT transporter, Pet1, MAOA) or indirectly (e.g., Neuropeptide Y, αCaMKII, NOS, BDNF). Dysfunction in genes for MAOA escalates pathological aggression in rodents and humans, particularly in interaction with specific experiences.
conclusionsFeedback to autoreceptors of the 5-HT(1) family and modulation via heteroreceptors are important in the expression of aggressive behavior. Tonic increase of the 5-HT(2) family expression may cause escalated aggression, whereas the phasic increase of 5-HT(2) receptors inhibits aggressive behaviors. Polymorphisms in the genes of 5-HT transporters or rate-limiting synthetic and metabolic enzymes of 5-HT modulate aggression, often requiring interaction with the rearing environment.
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Registered trials
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