ArticleCell research2011
Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone.
Article in Cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Adolescent Ethanol Exposure Disrupts the Mature Phenotype of Surviving Neuroprogenitors in Female Mice.Hippocampus · 2026Article
- BMSC exosomes promote neurogenesis and alleviate behavioral deficits in chronic traumatic encephalopathy: an animal model-based study.Stem cell research & therapy · 2026Article
- Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model.Translational psychiatry · 2026Article
- FlashTag-mediated Labeling for Intraventricular Macrophages in the Embryonic Brain.Bio-protocol · 2025Article
- Generation of a Dcx-CreERGenesis (New York, N.Y. : 2000) · 2024Article
- A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models.Cell reports · 2024Article
- Finding the right tool: a comprehensive evaluation of microglial inducible cre mouse models.bioRxiv : the preprint server for biology · 2023Article
- Article
- Loss of function of CMPK2 causes mitochondria deficiency and brain calcification.Cell discovery · 2022Article
- Insulin-like growth factor-1 overexpression increases long-term survival of posttrauma-born hippocampal neurons while inhibiting ectopic migration following traumatic brain injury.Acta neuropathologica communications · 2020Article
- Early detonation by sprouted mossy fibers enables aberrant dentate network activity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Short-Term Depression of Sprouted Mossy Fiber Synapses from Adult-Born Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- ADAM10-Initiated Release of Notch Intracellular Domain Regulates Microtubule Stability and Radial Migration of Cortical Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Nonspecific labeling limits the utility of Cre-Lox bred CST-YFP mice for studies of corticospinal tract regeneration.The Journal of comparative neurology · 2015Article
- Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury(1,2,3).eNeuro · 2015Article
- Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study.Cell death & disease · 2015Article
- Viral and transgenic reporters and genetic analysis of adult neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- Specificity and efficiency of reporter expression in adult neural progenitors vary substantially among nestin-CreER(T2) lines.The Journal of comparative neurology · 2014Article
- Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Manipulating the Mouse Genome Using Recombineering.Advancements in genetic engineering · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research over the past decades has demonstrated that adult brain produces neural progenitor cells which proliferate and differentiate to newborn neurons that integrate into the existing circuit. However, detailed differentiation processes and underlying mechanisms of newly generated neurons are largely unknown due to the limitation of available methods for labeling and manipulating neural progenitor cells and newborn neurons. In this study, we designed a tightly controlled, noninvasive system based on Cre/loxP recombination to achieve long-term tracing and genetic manipulation of adult neurons in vivo. In this system, tamoxifen-inducible recombinase, CreER(T2), was driven by BAC-based promoter of doublecortin (DCX, a marker of newborn neurons). By crossing this Cre line with reporter mouse, we found that newborn neurons in the dentate gyrus (DG) could be selectively pulse-labeled by tamoxifen-induced expression of yellow fluorescent protein (YFP). YFP-positive neurons were identified by coimmunostaining with cell type-specific markers and characterized by electrophysiological recording. Furthermore, analysis of the migration of these neurons showed that the majority of these labeled neurons migrated to the inner part of granule cell layer. Moreover, spine growth of inner molecular layer of newborn granule neurons takes a dynamic pattern of invert U-shape, in contrast to the wedge-shaped change in the outer molecular layer. Our transgenic tool provides an efficient way to selectively label and manipulate newborn neuron in adult mouse DG.
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