ReviewNature reviews. Microbiology2010
Identifying genetic markers of adaptation for surveillance of viral host jumps.
Review in Nature reviews. Microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influenza virus genotype to phenotype predictions through machine learning: a systematic review.Emerging microbes & infections · 2021Pooled it
- Pangolin-Associated Viruses: Diversity, Evolutionary Adaptation, and Zoonotic Spillover Risks.Animals : an open access journal from MDPI · 2026Review
- Combined generalist and host-specific transcriptional strategies enable host generalism in the fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Ecological factors and genetic features are associated with ecological generalism in pathogenic tick-borne viruses.Nature communications · 2026Article
- Genomic features associated with sustained mammalian transmission of avian influenza A viruses.Nature microbiology · 2026Article
- Pathogen host jump risk is not predicted by spillover rate, but rather by novelty.PLoS biology · 2026Article
- Engineering a mouse-adapted SADS-CoV and establishing a neonatal mouse model to study its infection.mBio · 2026Article
- Sequence based virus host prediction: a curated dataset and generalizable framework for training artificial intelligence to identify viruses of humans.Virus evolution · 2026Article
- The evolution and epidemiology of H3N2 canine influenza virus after 20 years in dogs.Epidemiology and infection · 2025Article
- Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV spikes and mediates host range expansion.Journal of virology · 2024Article
- Natural variation in infection specificity of Caenorhabditis briggsae isolates by two RNA viruses.PLoS pathogens · 2024Article
- The evolutionary drivers and correlates of viral host jumps.Nature ecology & evolution · 2024Article
- Article
- Understanding the divergent evolution and epidemiology of H3N8 influenza viruses in dogs and horses.Virus evolution · 2023Article
- Lethal Swine Acute Diarrhea Syndrome Coronavirus Infection in Suckling Mice.Journal of virology · 2022Article
- Ecology, evolution and spillover of coronaviruses from bats.Nature reviews. Microbiology · 2022Review
- The future of zoonotic risk prediction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- From Protein to Pandemic: The Transdisciplinary Approach Needed to Prevent Spillover and the Next Pandemic.Viruses · 2021Review
- SARS-CoV-2: Cross-scale Insights from Ecology and Evolution.Trends in microbiology · 2021Review
- Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses.Nature chemistry · 2021Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptation is often thought to affect the likelihood that a virus will be able to successfully emerge in a new host species. If so, surveillance for genetic markers of adaptation could help to predict the risk of disease emergence. However, adaptation is difficult to distinguish conclusively from the other processes that generate genetic change. In this Review we survey the research on the host jumps of influenza A, severe acute respiratory syndrome-coronavirus, canine parvovirus and Venezuelan equine encephalitis virus to illustrate the insights that can arise from combining genetic surveillance with microbiological experimentation in the context of epidemiological data. We argue that using a multidisciplinary approach for surveillance will provide a better understanding of when adaptations are required for host jumps and thus when predictive genetic markers may be present.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.