ArticleThe Journal of biological chemistry2010
A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Zinc excess promotes lysosome remodeling by activating HLH-30/TFEB through the action of the high zinc sensor HIZR-1.bioRxiv : the preprint server for biology · 2026Article
- The mrp-3 gene is involved in haem efflux and detoxification in a blood-feeding nematode.BMC biology · 2024Article
- Notes from the Underground: Heme Homeostasis inBiomolecules · 2023Review
- Haem transporter HRG-1 is essential in the barber's pole worm and an intervention target candidate.PLoS pathogens · 2023Article
- How affinity of the ELT-2 GATA factor binding toDevelopment (Cambridge, England) · 2020Article
- A pathway for low zinc homeostasis that is conserved in animals and acts in parallel to the pathway for high zinc homeostasis.Nucleic acids research · 2017Article
- Inter-organ signalling by HRG-7 promotes systemic haem homeostasis.Nature cell biology · 2017Article
- Heme acquisition in the parasitic filarial nematode Brugia malayi.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Cellular sensing and transport of metal ions: implications in micronutrient homeostasis.The Journal of nutritional biochemistry · 2015Review
- Lessons from bloodless worms: heme homeostasis in C. elegans.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2015Article
- A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans.Nucleic acids research · 2015Article
- DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage.Nature cell biology · 2014Article
- Control of metazoan heme homeostasis by a conserved multidrug resistance protein.Cell metabolism · 2014Article
- Heme and erythropoieis: more than a structural role.Haematologica · 2014Review
- Topologically conserved residues direct heme transport in HRG-1-related proteins.The Journal of biological chemistry · 2012Article
- HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage.PLoS genetics · 2011Article
- Article
- Heme and FLVCR-related transporter families SLC48 and SLC49.Molecular aspects of medicineReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hemes are prosthetic groups that participate in diverse biochemical pathways across phylogeny. Although heme can also regulate broad physiological processes by directly modulating gene expression in Metazoa, the regulatory pathways for sensing and responding to heme are not well defined. Caenorhabditis elegans is a heme auxotroph and relies solely on environmental heme for sustenance. Worms respond to heme availability by regulating heme-responsive genes such as hrg-1, an intestinal heme transporter that is up-regulated by >60-fold during heme depletion. To identify the mechanism for the heme-dependent regulation of hrg-1, we interrogated the hrg-1 promoter. Deletion and mutagenesis studies of the hrg-1 promoter revealed a 23-bp heme-responsive element that is both necessary and sufficient for heme-dependent regulation of hrg-1. Furthermore, our studies show that the heme regulation of hrg-1 is mediated by both activation and repression in conjunction with ELT-2 and ELT-4, transcription factors that specify intestinal expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.