Trial reportArchives of internal medicine2010
Pharmacist-physician comanagement of hypertension and reduction in 24-hour ambulatory blood pressures.
Trial report in Archives of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00201045 (Collaborative Management of Hypertension), which is not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Collaborative Management of Hypertension
Who cites it
45 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Pooled it
- Involving community pharmacists in interprofessional collaboration in primary care: a systematic review.BMC primary care · 2024Pooled it
- Interprofessional collaboration in primary care: what effect on patient health? A systematic literature review.BMC primary care · 2023Pooled it
- Nurse Practitioner-Physician Comanagement: A Theoretical Model to Alleviate Primary Care Strain.Annals of family medicine · 2018Pooled it
- Team-based care and improved blood pressure control: a community guide systematic review.American journal of preventive medicine · 2014Pooled it
- Effectiveness of Shared Decision-making for Diabetes Prevention: 12-Month Results from the Prediabetes Informed Decision and Education (PRIDE) Trial.Journal of general internal medicine · 2019Trial
- Pharmacist-based antihypertensive medication review and assignment of morning versus evening dosing of once-daily antihypertensive medications: A pilot study to assess feasibility and efficacy in chronic kidney disease patients.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2018Trial
- Short-term telemedical home blood pressure monitoring does not improve blood pressure in uncomplicated hypertensive patients.Journal of human hypertension · 2017Trial
- Team-based care for improving hypertension management among outpatients (TBC-HTA): study protocol for a pragmatic randomized controlled trial.BMC cardiovascular disorders · 2017Trial
- Physician-pharmacist co-management and 24-hour blood pressure control.Journal of clinical hypertension (Greenwich, Conn.) · 2013Trial
- Trial
- Reducing clinical inertia in hypertension treatment: a pragmatic randomized controlled trial.Journal of clinical hypertension (Greenwich, Conn.) · 2012Trial
- Health coaching to improve hypertension treatment in a low-income, minority population.Annals of family medicineTrial
- Key components of success in a randomized trial of blood pressure telemonitoring with medication therapy management pharmacists.Journal of the American Pharmacists Association : JAPhATrial
- A clinical trial evaluating pharmacist-guided self-management of hypertension among veterans with CKD, rationale and study design.Contemporary clinical trials · 2025Article
- Multilevel Interventions Demonstrate Mixed Effectiveness for Improving Blood Pressure Outcomes: A Rapid Review.Healthcare (Basel, Switzerland) · 2025Review
- Pharmacists delivering hypertension care services: a systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2025Article
- Effect of Pharmaceutical Intervention in Pharmacologically Treated Hypertensive Patients-A Cluster-Randomized Clinical Trial: AFPRES-CLM Study.Journal of personalized medicine · 2023Article
- A De Novo Pharmacist-Family Physician Collaboration Model in a Family Medicine Clinic in Alberta, Canada.Pharmacy (Basel, Switzerland) · 2021Article
- Implementation of Outpatient Pharmacist-led Hypertension Management for Under-Resourced Patients: A Pilot Study.Innovations in pharmacy · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundPharmacist-physician comanagement of hypertension has been shown to improve office blood pressures (BPs). We sought to describe the effect of such a model on 24-hour ambulatory BPs.
methodsWe performed a prospective, cluster-randomized, controlled clinical trial, enrolling 179 patients with uncontrolled hypertension from 5 primary care clinics in Iowa City, Iowa. Patients were randomized by clinic to receive pharmacist-physician collaborative management of hypertension (intervention) or usual care (control) for a 9-month period. In the intervention group, pharmacists helped patients to identify barriers to BP control, counseled on lifestyle and dietary modifications, and adjusted antihypertensive therapy in collaboration with the patients' primary care providers. Patients were seen by pharmacists a minimum of every 2 months. Ambulatory BP was measured at baseline and at study end.
resultsBaseline and end-of-study ambulatory BP profiles were evaluated for 175 patients. Mean (SD) ambulatory systolic BPs (SBPs), reported in millimeters of mercury, were reduced more in the intervention group than in the control group: daytime change in (Δ) SBP, 15.2 (11.5) vs 5.5 (13.5) (P < .001); nighttime ΔSBP, 12.2 (14.8) vs 3.4 (13.3) (P < .001); and 24-hour ΔSBP, 14.1 (11.3) vs 5.5 (12.5) (P < .001). More patients in the intervention group than in the control group had their BP controlled at the end of the study (75.0% vs 50.7%) (P < .001), as defined by overall 24-hour ambulatory BP monitoring.
conclusionPharmacist-physician collaborative management of hypertension achieved consistent and significantly greater reduction in 24-hour BP and a high rate of BP control. Trial Registration clinicaltrials.gov Identifier: NCT00201045.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.