ArticleProceedings of the National Academy of Sciences of the United States of America2010
Initiation of the proton pump of cytochrome c oxidase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Special Issue "Ion Pumps: Molecular Mechanisms, Structure, Physiology".International journal of molecular sciences · 2026Article
- The three-dimensional structure of a proton-pumping pathway, the H-pathway, is evolutionarily conserved in all three families of cytochromeFrontiers in chemistry · 2025Article
- Cell Phone Radiation Exposure Limits and Engineering Solutions.International journal of environmental research and public health · 2023Review
- Recent progress in experimental studies on the catalytic mechanism of cytochromeFrontiers in chemistry · 2023Review
- Proton Pumping and Non-Pumping Terminal Respiratory Oxidases: Active Sites Intermediates of These Molecular Machines and Their Derivatives.International journal of molecular sciences · 2021Review
- Probing the Proton-Loading Site of CytochromeMolecules (Basel, Switzerland) · 2020Article
- Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function.Chemical reviews · 2018Review
- Analyzing the electrogenicity of cytochrome c oxidase.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Multiscale simulations reveal key features of the proton-pumping mechanism in cytochrome c oxidase.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Conformational coupling between the active site and residues within the K(C)-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Characterizing the proton loading site in cytochrome c oxidase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Chromophore photoreduction in red fluorescent proteins is responsible for bleaching and phototoxicity.The journal of physical chemistry. B · 2014Article
- Functions of the hydrophilic channels in protonmotive cytochrome c oxidase.Journal of the Royal Society, Interface · 2013Review
- Exploring the proton pump and exit pathway for pumped protons in cytochrome ba3 from Thermus thermophilus.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Expanding the view of proton pumping in cytochrome c oxidase through computer simulation.Biochimica et biophysica acta · 2012Article
- Dynamic mechanism of proton transfer in mannitol 2-dehydrogenase from Pseudomonas fluorescens: mobile GLU292 controls proton relay through a water channel that connects the active site with bulk solvent.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome c oxidase is the terminal enzyme of the respiratory chain that is responsible for biological energy conversion in mitochondria and aerobic bacteria. The membrane-bound enzyme converts free energy from oxygen reduction to an electrochemical proton gradient by functioning as a redox-coupled proton pump. Although the 3D structure and functional studies have revealed proton conducting pathways in the enzyme interior, the location of proton donor and acceptor groups are not fully identified. We show here by time-resolved optical and FTIR spectroscopy combined with time-resolved electrometry that some mutant enzymes incapable of proton pumping nevertheless initiate catalysis by proton transfer to a proton-loading site. A conserved tyrosine in the so-called D-channel is identified as a potential proton donor that determines the efficiency of this reaction.
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