ArticleProceedings of the National Academy of Sciences of the United States of America2010
Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia.Communications biology · 2023Article
- Production of brain-derived neurotrophic factor gates plasticity in developing visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- microRNA-dependent regulation of gene expression in GABAergic interneurons.Frontiers in cellular neuroscience · 2023Review
- Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.Frontiers in neural circuits · 2021Review
- Ethanol actions on the ventral tegmental area: novel potential targets on reward pathway neurons.Psychopharmacology · 2018Review
- Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex.Scientific reports · 2017Article
- Article
- Nogo Receptor 1 Limits Ocular Dominance Plasticity but not Turnover of Axonal Boutons in a Model of Amblyopia.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?Neuroscience · 2014Review
- Article
- Genes and signaling pathways involved in memory enhancement in mutant mice.Molecular brain · 2014Review
- The role of nitric oxide in pre-synaptic plasticity and homeostasis.Frontiers in cellular neuroscience · 2013Review
- The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Review
- Homeostatic plasticity mechanisms are required for juvenile, but not adult, ocular dominance plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Ras-ERK Signaling in Behavior: Old Questions and New Perspectives.Frontiers in behavioral neuroscience · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Experience-dependent cortical plasticity has been studied by using loss-of-function methods. Here, we take the complementary approach of using a genetic gain-of-function that enhances plasticity. We show that a constitutively active form of H-ras (H-ras(G12V)), expressed presynaptically at excitatory synapses in mice, accelerates and enhances multiple, mechanistically distinct forms of plasticity in the developing visual cortex. In vivo, H-ras(G12V) not only increased the rate of ocular dominance change in response to monocular deprivation (MD), but also accelerated recovery from deprivation by reverse occlusion. In vitro, H-ras(G12V) expression decreased baseline presynaptic release probability and enhanced presynaptically expressed long-term potentiation (LTP). H-ras(G12V) expression also accelerated the increase following MD in the frequency of miniature excitatory potentials, mirroring accelerated plasticity in vivo. These findings demonstrate accelerated neocortical plasticity, which offers an avenue toward future therapies for many neurological and neuropsychiatric disorders.
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