ArticleThe Journal of biological chemistry2010
Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Novel compound heterozygous mutations in theWorld journal of clinical cases · 2024Article
- Expression of genes related to iron homeostasis in breast cancer.Molecular biology reports · 2023Article
- Review
- Article
- Regulation of Iron Homeostasis and Related Diseases.Mediators of inflammation · 2020Review
- The catalytic, stem, and transmembrane portions of matriptase-2 are required for suppressing the expression of the iron-regulatory hormone hepcidin.The Journal of biological chemistry · 2019Article
- Liver iron sensing and body iron homeostasis.Blood · 2019Review
- Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway.The Journal of biological chemistry · 2017Article
- RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.Trends in cell biology · 2017Review
- SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.BMC bioinformatics · 2017Review
- Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.The Journal of biological chemistry · 2016Article
- 3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach.Pharmaceuticals (Basel, Switzerland) · 2016Article
- The Impact of Acute Matriptase Inhibition in Hepatic Inflammatory Models.BioMed research international · 2016Article
- Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.Human molecular genetics · 2015Article
- Identification of TMPRSS6 cleavage sites of hemojuvelin.Journal of cellular and molecular medicine · 2015Article
- β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies.Haematologica · 2015Review
- Low intracellular iron increases the stability of matriptase-2.The Journal of biological chemistry · 2015Article
- Two middle-age-onset hemochromatosis patients with heterozygous mutations in the hemojuvelin gene in a Chinese family.International journal of hematology · 2014Article
- Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches.Hematology/oncology clinics of North America · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Hemojuvelin (HJV) is an important regulator of iron metabolism. Membrane-anchored HJV up-regulates expression of the iron regulatory hormone, hepcidin, through the bone morphogenic protein (BMP) signaling pathway by acting as a BMP co-receptor. HJV can be cleaved by the furin family of proprotein convertases, which releases a soluble form of HJV that suppresses BMP signaling and hepcidin expression by acting as a decoy that competes with membrane HJV for BMP ligands. Recent studies indicate that matriptase-2 binds and degrades HJV, leading to a decrease in cell surface HJV. In the present work, we show that matriptase-2 cleaves HJV at Arg(288), which produces one major soluble form of HJV. This shed form of HJV has decreased ability to bind BMP6 and does not suppress BMP6-induced hepcidin expression. These results suggest that the matriptase-2 and proprotein convertase-cleavage products have different roles in the regulation of hepcidin expression.
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