ArticleThe Journal of biological chemistry2010
Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Spatiotemporal control of cell ablation using Ronidazole with Nitroreductase in Drosophila.Developmental biology · 2025Article
- Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth.EMBO reports · 2024Article
- Article
- Gene expression correlates of facultative predation in the blow flyEcology and evolution · 2019Article
- Effects of hypo-The Journal of biological chemistry · 2018Article
- PAF1 complex component Leo1 helps recruitProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif.Oncogene · 2016Article
- snoRNAs are a novel class of biologically relevant Myc targets.BMC biology · 2015Article
- A role for the serine/arginine-rich (SR) protein B52/SRSF6 in cell growth and myc expression in Drosophila.Genetics · 2015Article
- Drosophila mbm is a nucleolar myc and casein kinase 2 target required for ribosome biogenesis and cell growth of central brain neuroblasts.Molecular and cellular biology · 2014Article
- Evidence for tissue-specific Jak/STAT target genes in Drosophila optic lobe development.Genetics · 2013Article
- Myc function in Drosophila.Cold Spring Harbor perspectives in medicine · 2013Review
- Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.Molecular biology of the cell · 2012Article
- Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Myc proto-oncoproteins are transcription factors that recognize numerous target genes through hexameric DNA sequences called E-boxes. The mechanism by which they then activate the expression of these targets is still under debate. Here, we use an RNAi screen in Drosophila S2 cells to identify Drosophila host cell factor (dHCF) as a novel co-factor for Myc that is functionally required for the activation of a Myc-dependent reporter construct. dHCF is also essential for the full activation of endogenous Myc target genes in S2 cells, and for the ability of Myc to promote growth in vivo. Myc and dHCF physically interact, and they colocalize on common target genes. Furthermore, down-regulation of dHCF-associated histone acetyltransferase and histone methyltransferase complexes in vivo interferes with the Myc biological activities. We therefore propose that dHCF recruits such chromatin-modifying complexes and thereby contributes to the expression of Myc targets and hence to the execution of Myc biological activities.
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