ArticleInfection and immunity2011
Characterization of a Staphylococcus aureus surface virulence factor that promotes resistance to oxidative killing and infectious endocarditis.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
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- Oleate Hydratase (OhyA) Is a Virulence Determinant in Staphylococcus aureus.Microbiology spectrum · 2021Article
- Fatty acids can inhibit Staphylococcus aureus SaeS activity at the membrane independent of alterations in respiration.Molecular microbiology · 2021Article
- New Insight into Genotypic and Phenotypic Relatedness ofPolish journal of microbiology · 2019Article
- Fulminant Staphylococcal Infections.Microbiology spectrum · 2018Review
- Messing with the Sentinels-The Interaction ofMicroorganisms · 2018Review
- Neutrophils: Beneficial and Harmful Cells in Septic Arthritis.International journal of molecular sciences · 2018Review
- Proteomics of Staphylococcus aureus biofilm matrix in a rat model of orthopedic implant-associated infection.PloS one · 2017Article
- Neutrophils and Immunity: From Bactericidal Action to Being Conquered.Journal of immunology research · 2017Review
- Control of Phagocytosis by Microbial Pathogens.Frontiers in immunology · 2017Review
- Article
- Extracellular traps and macrophages: new roles for the versatile phagocyte.Journal of leukocyte biology · 2015Review
- How methicillin-resistant Staphylococcus aureus evade neutrophil killing.Current opinion in hematology · 2015Review
- Bdellovibrio bacteriovorus inhibits Staphylococcus aureus biofilm formation and invasion into human epithelial cells.Scientific reports · 2014Article
- Article
- Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB).Genome research · 2012Article
- Mobilization of pathogenicity islands by Staphylococcus aureus strain Newman bacteriophages.Bacteriophage · 2012Article
- Analysis of murine genetic predisposition to pneumococcal infection reveals a critical role of alveolar macrophages in maintaining the sterility of the lower respiratory tract.Infection and immunity · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Staphylococcus aureus is a prominent human pathogen and a leading cause of community- and hospital-acquired bacterial infections worldwide. Herein, we describe the identification and characterization of the S. aureus 67.6-kDa hypothetical protein, named for the surface factor promoting resistance to oxidative killing (SOK) in this study. Sequence analysis showed that the SOK gene is conserved in all sequenced S. aureus strains and homologous to the myosin cross-reactive antigen of Streptococcus pyogenes. Immunoblotting and immunofluorescence analysis showed that SOK was copurified with membrane fractions and was exposed on the surface of S. aureus Newman and RN4220. Comparative analysis of wild-type S. aureus and an isogenic deletion strain indicated that SOK contributes to both resistance to killing by human neutrophils and to oxidative stress. In addition, the S. aureus sok deletion strain showed dramatically reduced aortic valve vegetation and bacterial cell number in a rabbit endocarditis model. These results, plus the suspected role of the streptococcal homologue in certain diseases such as acute rheumatic fever, suggest that SOK plays an important role in cardiovascular and other staphylococcal infections.
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Registered trials
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