ArticleThe Journal of physiology2010
Sympathetic neural activation: an ordered affair.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Microelectrode recordings from the human cervical vagus nerve during maximal breath-holds.Experimental physiology · 2026Article
- Dynamics of Preparatory Apneas and Their Influence on Maximal Dry Static Apnea in Breath-Hold Divers.Journal of functional morphology and kinesiology · 2025Article
- The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Sex differences in the relationship between pain and autonomic outflow during a cold pressor test.Biology of sex differences · 2025Article
- Carotid artery dissection linked to intermittent apnoeic swimming: A case-control study.Experimental physiology · 2025Article
- Aerobic and Anaerobic Metabolism During Monofin Swimming in Trained Breath-Hold Divers.Journal of functional morphology and kinesiology · 2025Article
- Human sympathetic neuronal discharge and recruitment patterns regulate neuropeptide Y bioavailability.American journal of physiology. Heart and circulatory physiology · 2024Article
- Interaction of simultaneous hypoxia and baroreflex loading on control of sympathetic action potential subpopulations.Journal of neurophysiology · 2024Article
- Central αThe Journal of physiology · 2024Article
- A comparison of wavelet-based action potential detection from the NeuroAmp and the Iowa Bioengineering Nerve Traffic Analysis system.Journal of neurophysiology · 2024Article
- A century of exercise physiology: key concepts in neural control of the circulation.European journal of applied physiology · 2024Review
- Construction and Validation of Newly Adapted Sport-Specific Anaerobic Diving Tests.Sports (Basel, Switzerland) · 2024Article
- Sympathetic neural reactivity to the Trier social stress test.The Journal of physiology · 2022Article
- Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Impaired sympathetic neural recruitment during exercise pressor reflex activation in women with post-traumatic stress disorder.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Acute changes in forearm vascular compliance during transient sympatho-excitation.Physiological reports · 2022Article
- The impact of ageing and sex on sympathetic neurocirculatory regulation.Seminars in cell & developmental biology · 2021Review
- Recording and quantifying sympathetic outflow to muscle and skin in humans: methods, caveats and challenges.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Review
- Breath-Hold Diving - The Physiology of Diving Deep and Returning.Frontiers in physiology · 2021Review
- Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults.Journal of neurophysiology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Is there an ordered pattern in the recruitment of postganglionic sympathetic neurones? Using new multi-unit action potential detection and analysis techniques we sought to determine whether the activation of sympathetic vasomotor neurones during stress is governed by the size principle of recruitment. Multi-unit postganglionic sympathetic activity (fibular nerve) was collected from five male subjects at rest and during periods of elevated sympathetic stress (end-inspiratory apnoeas; 178 ± 37 s(mean ± S.D.)). Compared to baseline (0.24 ± 0.04 V), periods of elevated stress resulted in augmented sympathetic burst size (1.34 ± 0.38 V, P < 0.05). Increased burst size was directly related to both the number of action potentials within a multi-unit burst of postganglionic sympathetic activity (r = 0.88 ± 0.04, P < 0.001 in all subjects), and the amplitude of detected action potentials (r = 0.88 ± 0.06, P < 0.001 in all subjects). The recruitment of larger, otherwise silent, neurons accounted for approximately 74% of the increase in detected action potentials across burst sizes. Further, action potential conduction velocities (inverse of latencies) were increased as a function of action potential size (R² = 0.936, P = 0.001). As axon diameter is positively correlated with action potential size and conduction velocity, these data suggest that the principle of ordered recruitment based on neuronal size applies to postganglionic sympathetic vasomotor neurones. This information may be pertinent to our understanding of reflex-specific recruitment strategies in postganglionic sympathetic nerves, patterns of vasomotor control during stress, and the malleability of sympathetic neuronal properties and recruitment in health and disease.
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