ArticleThe Journal of experimental medicine2010
The innate immune system in host mice targets cells with allogenic mitochondrial DNA.
Article in The Journal of experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Mesenchymal Stromal Cell-Derived Extracellular Vesicles Mediate Mitochondrial Delivery in Injury: Mechanistic Insights, Evidentiary Tiers, and Translational Challenges.Stem cell reviews and reports · 2026Review
- Imperial strategy of cancer cells through mitochondrial transfer.Molecular oncology · 2025Review
- Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cardiac Involvement in Mitochondrial Disorders.Current heart failure reports · 2023Review
- Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease.Journal of translational medicine · 2022Review
- Neither Donor nor Recipient Mitochondrial Haplotypes Are Associated with Unrelated Donor Transplant Outcomes: A Validation Study from the CIBMTR.Transplantation and cellular therapy · 2021Article
- A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation.International journal of molecular sciences · 2021Article
- Mitochondrial Transplantation Attenuates Cerebral Ischemia-Reperfusion Injury: Possible Involvement of Mitochondrial Component Separation.Oxidative medicine and cellular longevity · 2021Article
- Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies.Frontiers in cell and developmental biology · 2021Review
- An evolutionary, or "Mitocentric" perspective on cellular function and disease.Redox biology · 2020Review
- Mitochondrial DNA in inflammation and immunity.EMBO reports · 2020Review
- Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?Metabolic brain disease · 2019Review
- mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPRFrontiers in cell and developmental biology · 2017Review
- LRBA is Essential for Allogeneic Responses in Bone Marrow Transplantation.Scientific reports · 2016Article
- Human pluripotent stem cells: Towards therapeutic development for the treatment of lifestyle diseases.World journal of stem cells · 2016Review
- Mitochondria Know No Boundaries: Mechanisms and Functions of Intercellular Mitochondrial Transfer.Frontiers in cell and developmental biology · 2016Review
- The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2015Article
- Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs.Nature communications · 2015Article
- An exploratory analysis of mitochondrial haplotypes and allogeneic hematopoietic cell transplantation outcomes.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2015Article
- Innate immune activation by tissue injury and cell death in the setting of hematopoietic stem cell transplantation.Frontiers in immunology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutations have been associated with aging, tumors, and various disorders, but the effects of mtDNA imported into transplants from different individuals or aged subjects have been unclear. We examined this issue by generating trans-mitochondrial tumor cells and embryonic stem cells that shared the syngenic C57BL/6 (B6) strain-derived nuclear DNA background but possessed mtDNA derived from allogenic mouse strains. We demonstrate that transplants with mtDNA from the NZB/B1NJ strain were rejected from the host B6 mice, not by the acquired immune system but by the innate immune system. This rejection was caused partly by NK cells and involved a MyD88-dependent pathway. These results introduce novel roles of mtDNA and innate immunity in tumor immunology and transplantation medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.