ArticleThe Journal of experimental medicine2010
Tbata modulates thymic stromal cell proliferation and thymus function.
Article in The Journal of experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Human Organoids as a Novel Tool for Vaccine Study.Advanced healthcare materials · 2026Review
- Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Immune and Immune-Integrated Organoids as NextGeneration Platforms for Disease Modeling.MedComm · 2025Review
- Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals.Nature communications · 2024Article
- Mechanisms underlying the direct programming of mouse embryonic fibroblasts to thymic epithelial cells by FOXN1.Development (Cambridge, England) · 2024Article
- UBA3 promotes the occurrence and metastasis of intrahepatic cholangiocarcinoma through MAPK signaling pathway.Acta biochimica et biophysica Sinica · 2024Article
- A spatial human thymus cell atlas mapped to a continuous tissue axis.bioRxiv : the preprint server for biology · 2023Article
- Recent Advancements in Regenerative Approaches for Thymus Rejuvenation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Immunomodulatory effect ofExperimental and therapeutic medicine · 2018Article
- Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes.The Journal of experimental medicine · 2016Article
- Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.Nature immunology · 2016Article
- Restoration of Thymus Function with Bioengineered Thymus Organoids.Current stem cell reports · 2016Article
- Engineering approaches for regeneration of T lymphopoiesis.Biomaterials research · 2016Review
- Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Thymus and aging: morphological, radiological, and functional overview.Age (Dordrecht, Netherlands) · 2014Review
- Thymic epithelial cell development and differentiation: cellular and molecular regulation.Protein & cell · 2013Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Niche availability provided by stromal cells is critical to thymus function. Thymi with diminished function contain fewer stromal cells, whereas thymi with robust function contain proliferating stromal cell populations. Here, we show that the thymus, brain, and testes-associated gene (Tbata; also known as SPATIAL) regulates thymic epithelial cell (TEC) proliferation and thymus size. Tbata is expressed in thymic stromal cells and interacts with the enzyme Uba3, thereby inhibiting the Nedd8 pathway and cell proliferation. Thymi from aged Tbata-deficient mice are larger and contain more dividing TECs than wild-type littermate controls. In addition, thymic reconstitution after bone marrow transplantation occurred more rapidly in Rag2(-/-)Tbata(-/-) mice than in Rag2(-/-)Tbata(+/+) littermate controls. These findings suggest that Tbata modulates thymus function by regulating stromal cell proliferation via the Nedd8 pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.