ReviewPharmacological research2011
Using tetracyclines to treat osteoporotic/osteopenic bone loss: from the basic science laboratory to the clinic.
Review in Pharmacological research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00066027 (Low-Dose Doxycycline Effects on Osteopenic Bone Loss), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low-Dose Doxycycline Effects on Osteopenic Bone Loss
Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Serum bone biomarkers and oral/systemic bone loss in humans.Journal of dental research · 2011Trial
- Dual-function thermoresponsive antibiotic-loaded hydrogel with antimicrobial and osteogenic properties for implant-related infection control.Bioactive materials · 2026Article
- Alb-PRF Hybrid Membranes Functionalized with Carbonated Hydroxyapatite and Doxycycline for Bone Regeneration and Antimicrobial Control: An In Vitro Study.International journal of molecular sciences · 2026Article
- Proteases and Osteoporosis: A Comprehensive Review of Their Role in Bone Health.Current drug targets · 2025Review
- Effects of Minocycline Hydrochloride as an Adjuvant Therapy for a Guided Bone Augmentation Procedure in The Rat Calvarium.Dentistry journal · 2023Article
- Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore risks?Infection · 2021Review
- An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal.Diagnostics (Basel, Switzerland) · 2020Article
- The effect of low-level laser radiation and doxycycline on the levels of osteoprotegerin and receptor activator of nuclear factor kappa-B ligand.Lasers in medical science · 2020Article
- Periodontal therapeutics: Current host-modulation agents and future directions.Periodontology 2000 · 2020Review
- Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing.Bone research · 2020Article
- Drug-Loaded Elastin-Like Polypeptide-Collagen Hydrogels with High Modulus for Bone Tissue Engineering.Macromolecular bioscience · 2019Article
- Oxytetracycline versus Doxycycline Collagen Sponges Designed as Potential Carrier Supports in Biomedical Applications.Pharmaceutics · 2019Article
- Antibacterial, anti-inflammatory, and bone-regenerative dual-drug-loaded calcium phosphate nanocarriers-in vitro and in vivo studies.Drug delivery and translational research · 2018Article
- Doxycycline treatment in dialysis related amyloidosis: discrepancy between antalgic effect and inflammation, studied with FDG-positron emission tomography: a case report.BMC nephrology · 2017Article
- Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases.International dental journal · 2016Review
- Effects of long-term doxycycline on bone quality and strength in diabetic male DBA/2J mice.Bone reports · 2015Article
- A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: initial observations.Mediators of inflammation · 2014Article
- Anti-inflammatory Actions of Adjunctive Tetracyclines and Other Agents in Periodontitis and Associated Comorbidities.The open dentistry journal · 2014Article
- Osteoblast-targeted suppression of PPARγ increases osteogenesis through activation of mTOR signaling.Stem cells (Dayton, Ohio) · 2013Article
- Periodontal disease: linking the primary inflammation to bone loss.Clinical & developmental immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Periodontitis (progressive inflammatory disease characterized by alveolar bone loss, a major cause of tooth loss worldwide) is associated with both systemic osteoporosis and its milder form, osteopenia. Tetracyclines, by virtue of their non-antimicrobial pro-anabolic and anti-catabolic properties, are excellent candidate pharmaceuticals to simultaneously treat these local and systemic disorders. This paper reviews the foundational basic science and translational research which lead to a pivotal multicenter randomized clinical trial in postmenopausal women with both periodontitis and systemic (skeletal) osteopenia. This trial was designed primarily to examine whether subantimicrobial dose doxycycline (SDD) could reduce progressive alveolar (oral) bone loss associated with periodontitis and, secondarily, whether SDD could reduce systemic bone loss in the same subjects. This paper describes the efficacy and safety findings from this clinical trial and also outlines future directions using this promising and novel approach to manage both oral and systemic bone loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.