ArticleDevelopmental biology2011
Aubergine is a component of a nanos mRNA localization complex.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Discrete 3' UTR sequence motifs regulate nanos RNA enrichment in Drosophila germ granules.Developmental biology · 2026Article
- Non-gonadal PIWIL1/Aubergine drives regenerative and tumorigenic stem cell proliferation and tumorigenesis in the intestine.Cell reports · 2026Article
- Abundant piRNA production mediated by theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- In vivo Dicer-2 interactome during viral infection reveals novel pro and antiviral factors in Drosophila melanogaster.PLoS pathogens · 2025Article
- Review
- Direct observation of translational activation by a ribonucleoprotein granule.Nature cell biology · 2024Article
- Structural and functional organization of germ plasm condensates.The Biochemical journal · 2022Review
- Computational modeling offers new insight into Drosophila germ granule development.Biophysical journal · 2022Article
- CompartmentalizedeLife · 2020Article
- Protein components of ribonucleoprotein granules from Drosophila germ cells oligomerize and show distinct spatial organization during germline development.Scientific reports · 2019Article
- Nanos genes and their role in development and beyond.Cellular and molecular life sciences : CMLS · 2018Review
- Review
- piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm.Nature communications · 2017Article
- C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility.BMC biology · 2017Article
- Article
- Article
- Novel mutants of the aubergine gene.Fly · 2016Article
- In the right place at the right time: visualizing and understanding mRNA localization.Nature reviews. Molecular cell biology · 2015Review
- The biology of the germ line in echinoderms.Molecular reproduction and development · 2014Review
- The RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner.Journal of cell science · 2014Article
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6 authors.
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Abstract
Localization of nanos (nos) mRNA to the posterior pole of the Drosophila oocyte is essential for abdominal segmentation and germline development during embryogenesis. Posterior localization is mediated by a complex cis-acting localization signal in the nos 3' untranslated region that comprises multiple partially redundant elements. Genetic analysis suggests that this signal is recognized by RNA-binding proteins and associated factors that package nos mRNA into a localization competent ribonucleoprotein complex. However, functional redundancy among localization elements has made the identification of individual localization factors difficult. Indeed, only a single direct-acting nos localization factor, Rumpelstiltskin (Rump), has been identified thus far. Through a sensitized genetic screen, we have now identified the Argonaute family member Aubergine (Aub) as a nos localization factor. Aub interacts with nos mRNA in vivo and co-purifies with Rump in an RNA-dependent manner. Our results support a role for Aub, independent of its function in RNA silencing, as a component of a nos mRNA localization complex.
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