Trial reportThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2010
Low BMI and falling BMI predict HIV-associated tuberculosis: a prospective study in Tanzania.
Trial report in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Body mass index and tuberculosis risk: an updated systematic literature review and dose-response meta-analysis.International journal of epidemiology · 2025Pooled it
- Undernutrition as a risk factor for tuberculosis disease.The Cochrane database of systematic reviews · 2024Pooled it
- Three months of weekly rifapentine and isoniazid for treatment of Mycobacterium tuberculosis infection in HIV-coinfected persons.AIDS (London, England) · 2016Trial
- Article
- Perceived stigma and the role of BMI on perceived HIV-related stigma among people living with HIV/AIDS in Southeast Ethiopia.Frontiers in psychiatry · 2025Article
- A model for predicting high BMI of people living with HIV after receiving antiretroviral therapy.Therapeutic advances in chronic disease · 2022Article
- Article
- Assessing the Impact of Isoniazid Preventive Therapy (IPT) on Tuberculosis Incidence and Predictors of Tuberculosis among Adult Patients Enrolled on ART in Nekemte Town, Western Ethiopia: A Retrospective Cohort Study.Interdisciplinary perspectives on infectious diseases · 2019Article
- Article
- Observational
- Vitamin D and the promoter methylation of its metabolic pathway genes in association with the risk and prognosis of tuberculosis.Clinical epigenetics · 2018Article
- Article
- Association of Body Mass Index with the Tuberculosis Infection: a Population-based Study among 17796 Adults in Rural China.Scientific reports · 2017Article
- Predictors of tuberculosis and human immunodeficiency virus co-infection: a case-control study.Epidemiology and health · 2014Article
- Nutritional status of HIV-infected women with tuberculosis in Dar es Salaam, Tanzania.Public health action · 2013Article
- Article
- Article
- Mortality and health outcomes in HIV-infected and HIV-uninfected mothers at 18-20 months postpartum in Zomba District, Malawi.PloS one · 2012Article
- Optimal treatment of Codisease due to HIV and tuberculosis.The Journal of infectious diseases · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundLow body mass index (BMI) is a known risk factor for tuberculosis (TB) in people without human immunodeficiency virus (HIV), but there are no prospective studies linking BMI to the risk of HIV-associated TB.
designIn HIV-infected adults with CD4 counts ≥ 200 cells/μl receiving placebo in a TB booster vaccine trial in Dar es Salaam, Tanzania, we measured BMI at baseline and Year 1, and related baseline BMI and change in BMI to the risk of developing TB.
resultsWe documented 92 cases of TB among 979 subjects followed for a mean of 3.2 years. Compared to subjects who did not develop TB, subjects who developed TB had a lower baseline BMI (23.2 vs. 24.6 kg/m(2), P = 0.006), and a greater BMI decline from baseline to Year 1 (-0.4 vs. 0.6 kg/m(2), P < 0.001). In multivariate analyses, baseline BMI was associated with the risk of developing TB (hazard ratio [HR] per kg/m(2) 0.94, 95%CI 0.90-0.99, P = 0.028), as was the change in BMI from baseline to Year 1 (HR per kg/m(2) 0.79, 95%CI 0.71-0.87, P < 0.001). Subjects with a baseline BMI < 17 kg/m(2) were more likely to develop TB (HR 3.72, 95%CI 1.16-12.0, P = 0.028).
conclusionLow and falling BMI predict HIV-associated TB.
Indexed as
Identifiers
20937186PMC3068293W1891146434What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.