ArticleBMC genomics2010
Response of swine spleen to Streptococcus suis infection revealed by transcription analysis.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Mechanistic Landscape and Farm to Fork Control Strategies forTransboundary and emerging diseases · 2026Review
- Review
- Identifying transcriptomic profiles in ovine spleen after repetitive vaccination.Frontiers in immunology · 2024Article
- Dihydroartemisinin ameliorates innate inflammatory response induced byJournal of pharmaceutical analysis · 2023Article
- Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain.Veterinary research · 2021Article
- A Comparative Transcriptome Analysis of Human and Porcine Choroid Plexus Cells in Response toFrontiers in cellular and infection microbiology · 2021Article
- In vivo transcriptomes of Streptococcus suis reveal genes required for niche-specific adaptation and pathogenesis.Virulence · 2019Article
- Article
- Triggering Receptor Expressed on Myeloid Cells-1 Signaling: Protective and Pathogenic Roles on Streptococcal Toxic-Shock-Like Syndrome Caused byFrontiers in immunology · 2018Review
- Transcription analysis of the responses of porcine heart to Erysipelothrix rhusiopathiae.PloS one · 2017Article
- Type I Interferon Induced byFrontiers in immunology · 2017Article
- TREM-1 signaling promotes host defense during the early stage of infection with highly pathogenic Streptococcus suis.Infection and immunity · 2015Article
- Current transcriptomics in pig immunity research.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Review
- Targeting TREM-1 Signaling in the Presence of Antibiotics is Effective Against Streptococcal Toxic-Shock-Like Syndrome (STSLS) Caused by Streptococcus suis.Frontiers in cellular and infection microbiology · 2015Article
- Article
- A novel pro-inflammatory protein of Streptococcus suis 2 induces the Toll-like receptor 2-dependent expression of pro-inflammatory cytokines in RAW 264.7 macrophages via activation of ERK1/2 pathway.Frontiers in microbiology · 2015Article
- Breed-specific transcriptome response of spleen from six to eight week old piglet after infection with Streptococcus suis type 2.Molecular biology reports · 2014Article
- Transcription analysis of the porcine alveolar macrophage response to porcine circovirus type 2.BMC genomics · 2013Article
- Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis.BMC genomics · 2012Article
- HP0197 contributes to CPS synthesis and the virulence of Streptococcus suis via CcpA.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStreptococcus suis serotype 2 (SS2), a major swine pathogen and an emerging zoonotic agent, has greatly challenged global public health. Systematical information about host immune response to the infection is important for understanding the molecular mechanism of diseases.
results104 and 129 unique genes were significantly up-regulated and down-regulated in the spleens of pigs infected with SS2 (WT). The up-regulated genes were principally related to immune response, such as genes involved in inflammatory response; acute-phase/immune response; cell adhesion and response to stress. The down-regulated genes were mainly involved in transcription, transport, material and energy metabolism which were representative of the reduced vital activity of SS2-influenced cells. Only a few genes showed significantly differential expression when comparing avirulent isogenic strain (ΔHP0197) with mock-infected samples.
conclusionsOur findings indicated that highly pathogenic SS2 could persistently induce cytokines mainly by Toll-like receptor 2 (TLR2) pathway, and the phagocytosis-resistant bacteria could induce high level of cytokines and secrete toxins to destroy deep tissues, and cause meningitis, septicaemia, pneumonia, endocarditis, and arthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.