ArticleThe aging male : the official journal of the International Society for the Study of the Aging Male2011
Gonadal status and physical performance in older men.
Article in The aging male : the official journal of the International Society for the Study of the Aging Male, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predicting low testosterone in aging men: a systematic review.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Pooled it
- Compared to total serum testosterone, calculated free testosterone has a stronger association with lean mass, muscle strength, power, and physical function in older men.Aging clinical and experimental research · 2025Article
- Gonadotropins at Advanced Age - Perhaps They Are Not So Bad? Correlations Between Gonadotropins and Sarcopenia Indicators in Older Adults.Frontiers in endocrinology · 2021Article
- Gender difference and correlation between sexuality, thyroid hormones, cognitive, and physical functions in elderly fit.Journal of endocrinological investigation · 2019Article
- Sport, doping and male fertility.Reproductive biology and endocrinology : RB&E · 2018Review
- Article
- Aging and sex hormones in males.Virulence · 2017Review
- The Role of the Multiple Hormonal Dysregulation in the Onset of "Anemia of Aging": Focus on Testosterone, IGF-1, and Thyroid Hormones.International journal of endocrinology · 2015Review
- Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases.The lancet. Diabetes & endocrinology · 2014Review
- Physiology and its importance for reference intervals.The Clinical biochemist. Reviews · 2014Review
- Pulmonary rehabilitation: the reference therapy for undernourished patients with chronic obstructive pulmonary disease.BioMed research international · 2014Review
- Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons.Current pharmaceutical design · 2014Review
- Testosterone replacement therapy among elderly males: the Testim Registry in the US (TRiUS).Clinical interventions in aging · 2012Article
- Androgen effects on skeletal muscle: implications for the development and management of frailty.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectiveTo test the relationship between gonadal status and objective measures and determinants of physical performance in older men and their determinants.
methodsThe study included 455 ≥ 65 year older men of InCHIANTI study, Italy, with complete data on testosterone levels, hand grip strength, cross-sectional muscle area (CSMA), short physical performance battery (SPPB). Linear models were used to test the relationship between gonadal status and determinants of physical performance.
resultsThree different groups of older men were created: (1) severely hypogonadal (N=23), total testosterone levels ≤ 230 ng /dl; (2) moderately hypogonadal (N=88), total testosterone >230 and < 350 ng/dl) and (3) eugonadal (N=344), testosterone levels ≥ 350 ng/dl. With increased severity of hypogonadal status, participants were significantly older while their BMI was substantially similar. In the age and BMI adjusted analysis, there was a significant difference in haemoglobin levels, hand grip strength and SPPB score (p for trend < 0.001) among three groups, with severely hypogonadal men having lower values of haemoglobin, muscle strength and physical performance. We found no association between testosterone group assignment and calf muscle mass and 4 m walking speed. In the multivariate analysis grip strength (p for trend = 0.004) and haemoglobin (p for trend < 0.0001) but not SPPB and other determinants of physical performance were significantly different between the three groups.
conclusionsIn older men, gonadal status is independently associated with some determinants (haemoglobin and muscle strength) of physical performance.
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