ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2010
Exhaled NO among inner-city children in New York City.
Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee.The Journal of allergy and clinical immunology · 2023Article
- Second-hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine.Environmental health perspectives · 2015Review
- Role of biomarkers in understanding and treating children with asthma: towards personalized care.Pharmacogenomics and personalized medicine · 2013Review
- Gender and age affect the levels of exhaled nitric oxide in healthy children.Experimental and therapeutic medicine · 2013Article
- Storage conditions for stability of offline measurement of fractional exhaled nitric oxide after collection for epidemiologic research.BMC pulmonary medicine · 2012Article
- Children's urinary phthalate metabolites and fractional exhaled nitric oxide in an urban cohort.American journal of respiratory and critical care medicine · 2012Article
- Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohort.Environment international · 2012Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFractional exhaled nitric oxide (FeNO) has been proposed as a biomarker of airway inflammation for cohort studies of asthma.
objectivesTo assess the association between FeNO and asthma symptoms among 7-year-old children living in an inner-city community. To test the association between environmental tobacco smoke (ETS) exposure (previous and current) and FeNO among these children.
methodsAs part of a longitudinal study of asthma, children recruited in Head Start centers at age 4 had offline FeNO and lung function testing at age 7. Children with allergen-specific immunoglobulin E (IgE) (≥0.35 IU/mL) at age 7 were considered seroatopic. ETS exposure at ages 4 and 7 was assessed by questionnaire.
resultsOf 144 participating children, 89 had complete questionnaire data and achieved valid FeNO and lung function tests. Children with reported wheeze in the previous 12 months (n = 19) had higher FeNO than those without wheeze (n = 70) (geometric means 17.0 vs. 11.0 ppb, p = .005). FeNO remained significantly associated with wheeze (p = .031), after adjusting for seroatopy and forced expiratory volume in 1 second (FEV₁) in multivariable regression. FeNO at age 7 was positively associated with domestic ETS exposure at age 4 (29%) (β = 0.36, p = .015) but inversely associated with ETS exposure at age 7 (16%) (β = -0.74, p < .001).
conclusionsGiven its association with current wheeze, independent of seroatopy and lung function, FeNO provides a relevant outcome measure for studies in inner-city communities. While compelling, the positive association between ETS exposure at age 4 and a marker of airway inflammation at age 7 should be confirmed in a larger study.
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