ArticleDevelopmental neurobiology2011
Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
Article in Developmental neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
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- Exploratory Analysis of MicroRNA Alterations in a Neurodevelopmental Mouse Model for Autism Spectrum Disorder and Schizophrenia.International journal of molecular sciences · 2024Article
- Involvement of brain cell phenotypes in stress-vulnerability and resilience.Frontiers in neuroscience · 2023Review
- Hippocampal circuit dysfunction in psychosis.Translational psychiatry · 2022Review
- Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia.Molecular psychiatry · 2022Review
- Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex.Brain structure & function · 2021Article
- Mean Diffusivity in Striatum Correlates With Acute Neuronal Death but Not Lesser Neuronal Injury in a Pilot Study of Neonatal Piglets With Encephalopathy.Journal of magnetic resonance imaging : JMRI · 2020Article
- Deletion of the Mitochondrial Matrix Protein CyclophilinD Prevents Parvalbumin Interneuron Dysfunctionand Cognitive Deficits in a Mouse Model of NMDA Hypofunction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Conditional GSK3β deletion in parvalbumin-expressing interneurons potentiates excitatory synaptic function and learning in adult mice.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors.Cell reports · 2018Article
- Novel rare variations in genes that regulate developmental change in N-methyl-d-aspartate receptor in patients with schizophrenia.Human genome variation · 2018Article
- Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder.Molecular psychiatry · 2017Article
- Neuronal activity controls the development of interneurons in the somatosensory cortex.Frontiers in biology · 2016Article
- Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology?Schizophrenia research · 2016Review
- COMT val158met polymorphism and molecular alterations in the human dorsolateral prefrontal cortex: Differences in controls and in schizophrenia.Schizophrenia research · 2016Article
- Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits.Biological psychiatry · 2016Article
- Functional Uncoupling NMDAR NR2A Subunit from PSD-95 in the Prefrontal Cortex: Effects on Behavioral Dysfunction and Parvalbumin Loss after Early-Life Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders.Molecular psychiatry · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The goals of this research are to (1) determine the changes in the composition of NMDA receptor (NMDAR) subunits in GABAergic interneurons during critical period (CP); and (2) test the effect of chronic blockage of specific NR2 subunits on the maturation of specific GABAergic interneurons. Our data demonstrate that: (1) The amplitude of NMDAR mediated EPSCs (EPSCs(NMDAR) ) was significantly larger in the postCP group. (2) The coefficient of variation (CV), τ(decay) and half-width of EPSCs(NMDAR) were significantly larger in the preCP group. (3) A leftward shift in the half-activation voltages in the postCP vs. preCP group. (4) Using subunit-specific antagonists, we found a postnatal shift in NR2 composition towards more NR2A mediated EPSCs(NMDAR) . These changes occurred within a two-day narrow window of CP and were similar between fast-spiking (FS) and regular spiking (RSNP) interneurons. (5) Chronic blockage of NR2A, but not NR2B, decreased the expression of parvalbumin (PV), but not other calcium binding proteins in layer 2/3 and 4 of barrel cortex. (6) Chronic blockage of NR2A selectively affected the maturation of IPSCs mediated by FS cells. In summary, we have reported, for the first time, developmental changes in the molecular composition of NMDA NR2 subunits in interneurons during CP, and the effects of chronic blockage of NR2A but not NR2B on PV expression and inhibitory synaptic transmission from FS cells. These results support an important role of NR2A subunits in developmental plasticity of fast-spiking GABAergic circuits during CP.
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