ArticleCancer causes & control : CCC2010
Toenail selenium status and the risk of Barrett's esophagus: the Netherlands Cohort Study.
Article in Cancer causes & control : CCC, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Selenium for preventing cancer.The Cochrane database of systematic reviews · 2018Pooled it
- A review of dietary selenium intake and selenium status in Europe and the Middle East.Nutrients · 2015Pooled it
- Selenium for preventing cancer.The Cochrane database of systematic reviews · 2014Pooled it
- Trial
- Potential relationship between the selenoproteome and cancer.Molecular and clinical oncology · 2020Article
- Dietary Risk Reduction Factors for the Barrett's Esophagus-Esophageal Adenocarcinoma Continuum: A Review of the Recent Literature.Current nutrition reports · 2015Article
- Diet and esophageal disease.Annals of the New York Academy of Sciences · 2014Article
- Imagine a world without cancer.BMC cancer · 2014Article
- Toenail trace element status and risk of Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study.International journal of cancer · 2012Article
- The association between selenium and lipid levels: a longitudinal study in rural elderly Chinese.Archives of gerontology and geriatricsArticle
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between selenium and the risk of Barrett's esophagus (BE), the precursor lesion of esophageal adenocarcinoma.
methodsData from the prospective Netherlands Cohort Study were used. This cohort study was initiated in 1986, when 120,852 subjects aged 55-69 years completed a questionnaire on dietary habits and lifestyle, and provided toenail clippings for the determination of baseline selenium status. After 16.3 years of follow-up, 253 BE cases (identified through linkage with the nationwide Dutch pathology registry) and 2,039 subcohort members were available for case-cohort analysis. Cox proportional hazards models were used to calculate incidence rate ratios (RR).
resultsThe multivariable-adjusted RR for the highest versus the lowest quartile of toenail selenium was 1.06 (95% CI 0.71-1.57). No dose-response trend was seen (p trend = 0.99). No association was found in subgroups defined by sex, smoking status, body mass index (BMI), or intake of antioxidants. For BE cases that later progressed to high-grade dysplasia or adenocarcinoma, the RR for a selenium level above the median vs. below the median was 0.64 (95% CI 0.24-1.76).
conclusionsIn this large prospective cohort study, we found no evidence of an association between selenium and risk of BE.
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