ReviewClinical rheumatology2011
Review of current therapies for secondary hypertrophic pulmonary osteoarthropathy.
Review in Clinical rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Pooled it
- Clinical benefit of paclitaxel/carboplatin plus bevacizumab with zoledronic acid in pulmonary epithelioid hemangioendothelioma complicated by hypertrophic pulmonary osteoarthropathy and cardiac tamponade: a case report.Frontiers in oncology · 2026Article
- Hypertrophic Osteopathy Associated With Intrathoracic Masses in 5 Dogs and Review of the Literature.Veterinary medicine international · 2026Review
- Hypertrophic osteoarthropathy.Archives of medical science : AMS · 2023Article
- Article
- Hypertrophic osteoarthropathy in renal cell carcinoma - A case report.Anesthesia and pain medicine · 2021Article
- Hypertrophic Osteoarthropathy: A Secondary Manifestation of Malignant Melanoma.Case reports in rheumatology · 2021Article
- Recurrent hypertrophic pulmonary osteoarthropathy in an adult with bronchiectasis.Respirology case reports · 2020Article
- Successful Treatment of ROS1-rearranged Lung Cancer Complicated by Hypertrophic Pulmonary Osteoarthropathy with Crizotinib Therapy.Internal medicine (Tokyo, Japan) · 2019Article
- Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature.BMC musculoskeletal disorders · 2018Review
- [Paraneoplastic syndromes in rheumatology].Der Internist · 2018Review
- Hypertrophic Osteoarthropathy: an Unusual Cause of Knee Pain and Recurrent Effusion.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2016Article
- The lung cancer nurse role in the management of paraneoplastic syndromes in lung cancer.Translational lung cancer research · 2016Review
- Hypertrophic osteoarthropathy in patient with Crohn's disease: a case report.Journal of bone metabolism · 2014Article
- Hypertrophic osteoarthropathy and congenital heart disease: this is not casual.BMJ case reports · 2013Article
- [Bronchial carcinoma and knee pain. Secondary hypertrophic osteoarthropathy].Der Unfallchirurg · 2013Article
- Primary hypertrophic osteoarthropathy: an update.Frontiers of medicine · 2013Review
- Hypertrophic osteoarthropathy presenting as unilateral cellulitis with successful treatment using pamidronate disodium.The Journal of clinical and aesthetic dermatology · 2012Article
- [Hypertrophic osteoarthropathy. Bamberger-Marie disease].Zeitschrift fur Rheumatologie · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertrophic osteoarthropathy (HOA) is a disabling condition that may occur secondarily to primary lung cancer. It is characterized by digital clubbing, arthralgia/arthritis, and periostosis of the tubular bones. The pain associated with HOA can be disabling and often refractory to conventional analgesics. We performed a comprehensive review of the literature using the PubMed database on treatment modalities available for HOA. We found 52 relevant articles-40 case reports, six case series, two review papers, and four combined case series and review papers. There were no randomized controlled trials reported. We then classified treatments used for HOA into two categories: (1) treatment of primary cause (i.e., resection of tumor, chemotherapy, radiotherapy, treatment of infection, etc.) and (2) symptomatic treatments (i.e., bisphosphonates, octreotide, NSAIDs, vagotomy, etc.). Subsequently, we summarized the main findings for each treatment. Although the clinical diagnosis of HOA has existed for over 100 years, the pathogenesis mechanism has not yet been elucidated, and treatment options for this condition remain experimental. Primary treatment is the most widely reported modality to be efficacious. In cases which primary therapy is not possible, several symptomatic treatment modalities are suggested, with various degree of success. Further research is needed to clarify the pathophysiological mechanism of HOA as to appropriately direct therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.