ArticleDigestive diseases and sciences2011
The neutrophil respiratory burst and bacterial digestion in Crohn's disease.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Neutrophils: from IBD to the gut microbiota.Nature reviews. Gastroenterology & hepatology · 2024Review
- Bacterial Translocation as Inflammatory Driver in Crohn's Disease.Frontiers in cell and developmental biology · 2021Review
- Neutrophil Extracellular Traps in Inflammatory Bowel Disease: Pathogenic Mechanisms and Clinical Translation.Cellular and molecular gastroenterology and hepatology · 2021Review
- Recruitment of activated neutrophils correlates with disease severity in adult Crohn's disease.Clinical and experimental immunology · 2019Article
- Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn's Disease.Gastroenterology · 2018Article
- The Dual Role of Neutrophils in Inflammatory Bowel Diseases.Journal of clinical medicine · 2016Review
- Dietary Fiber Intake is Associated with Increased Colonic Mucosal GPR43+ Polymorphonuclear Infiltration in Active Crohn's Disease.Nutrients · 2015Article
- The role of polymorphonuclear leukocyte trafficking in the perpetuation of inflammation during inflammatory bowel disease.Inflammatory bowel diseases · 2013Review
- Article
- What is wrong with granulocytes in inflammatory bowel diseases?Digestive diseases (Basel, Switzerland) · 2013Review
- p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The neutrophil respiratory burst and bacterial digestion in Crohn's disease.Digestive diseases and sciences · 2011Article
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7 authors at 2 institutions in 2 countries.
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Abstract
backgroundNeutrophils are a key part of the innate immune defence against microbes, using the respiratory burst (RB) to optimise killing and digestion. Previous studies of the neutrophil RB in Crohn's disease (CD) have yielded conflicting results.
methodsSuperoxide production in response to phorbol-myristyl acetate (PMA) was measured in neutrophils from 100 patients with CD compared to 50 healthy controls (HCs) and 50 patients with ulcerative colitis (UC). A further 22 CD and 10 HCs were studied using f-Met-Leu-Phe (fMLP), and digestion of E. coli by neutrophils was also evaluated.
resultsThe mean ± SEM PMA-stimulated RB (nmol O(2)/10(6) cells/min) was 10.86 ± 0.26 in HCs, 9.76 ± 0.23 in CD (P=0.02) and 10.04 ± 0.28 in UC (P=0.09 vs HC and 0.47 vs CD). No significant effect of age, gender or medication was observed. The RB in three patients with presumed CD was found to be in the range expected in patients with inherited neutrophil disorders. Stimulation with fMLP was calcium dependent and attenuated in patients on 5-ASA. Digestion of E. coli by neutrophils was not different in HC vs CD (21.6 vs 20.53%, P=0.60).
conclusionThe significant reduction in neutrophil RB in CD does not appear to result in defective bacterial digestion and is therefore unlikely play a major role in pathogenesis. Three patients in this cohort of patients with presumed idiopathic CD were found to have a profound defect of the neutrophil RB. A high index of suspicion for such patients is prudent, as their prognosis can be improved by altering or augmenting the conventional treatment regimens employed for CD.
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