ArticleJournal of biomedicine & biotechnology2011
Navigating the human metabolome for biomarker identification and design of pharmaceutical molecules.
Article in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Human Respiratory Microbiome: Current Understandings and Future Directions.American journal of respiratory cell and molecular biology · 2023Pooled it
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- MR spectroscopy in breast cancer metabolomics.Analytical science advances · 2021Review
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- Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study.JMIR research protocols · 2021Article
- Screening of Altered Metabolites and Metabolic Pathways in Celiac Disease Using NMR Spectroscopy.BioMed research international · 2021Article
- Encoding information in synthetic metabolomes.PloS one · 2019Article
- Multiplatform metabolomic fingerprinting as a tool for understanding hypercholesterolemia in Wistar rats.European journal of nutrition · 2016Article
- In Vitro Analysis of Metabolites Secreted during Infection of Lung Epithelial Cells by Cryptococcus neoformans.PloS one · 2016Article
- Biomarkers of Nutrition for Development-Folate Review.The Journal of nutrition · 2015Review
- Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery.Drug discovery today · 2014Review
- Data Mining Methods for Omics and Knowledge of Crude Medicinal Plants toward Big Data Biology.Computational and structural biotechnology journal · 2013Review
- In-silico studies in Chinese herbal medicines' research: evaluation of in-silico methodologies and phytochemical data sources, and a review of research to date.Journal of ethnopharmacology · 2012Review
- The use of graph matching algorithms to identify biochemical substructures in synthetic chemical compounds: Application to metabolomics.IEEE ... International Conference on Computational Advances in Bio and Medical Sciences : [proceedings]. IEEE International Conference on Computational Advances in Bio and Medical Sciences · 2012Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolomics is a rapidly evolving discipline that involves the systematic study of endogenous small molecules that characterize the metabolic pathways of biological systems. The study of metabolism at a global level has the potential to contribute significantly to biomedical research, clinical medical practice, as well as drug discovery. In this paper, we present the most up-to-date metabolite and metabolic pathway resources, and we summarize the statistical, and machine-learning tools used for the analysis of data from clinical metabolomics. Through specific applications on cancer, diabetes, neurological and other diseases, we demonstrate how these tools can facilitate diagnosis and identification of potential biomarkers for use within disease diagnosis. Additionally, we discuss the increasing importance of the integration of metabolomics data in drug discovery. On a case-study based on the Human Metabolome Database (HMDB) and the Chinese Natural Product Database (CNPD), we demonstrate the close relatedness of the two data sets of compounds, and we further illustrate how structural similarity with human metabolites could assist in the design of novel pharmaceuticals and the elucidation of the molecular mechanisms of medicinal plants.
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