ArticleClinical & developmental immunology2011
Changing concepts of "latent tuberculosis infection" in patients living with HIV infection.
Article in Clinical & developmental immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Subclinical tuberculosis among adults with HIV: clinical features and outcomes in a South African cohort.BMC infectious diseases · 2019Trial
- Systemic immune activation and microbial translocation in dual HIV/tuberculosis-infected subjects.The Journal of infectious diseases · 2013Trial
- Health Service Contracting in the Prevention and Treatment of Tuberculosis: A Scoping Review.Journal of multidisciplinary healthcare · 2025Review
- Article
- Beyond latent and active tuberculosis: a scoping review of conceptual frameworks.EClinicalMedicine · 2023Article
- Interferon Gamma Release Assay and Tuberculin Skin Test Performance in Pregnant Women Living With and Without HIV.Journal of acquired immune deficiency syndromes (1999) · 2022Article
- Coverage and fidelity of the Xpert MTB/RIF™ implementation in a high-burden area for pulmonary tuberculosis in ColombiaBiomedica : revista del Instituto Nacional de Salud · 2020Article
- Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study.AIDS research and treatment · 2020Article
- "Tuberculosis in advanced HIV infection is associated with increased expression of IFNγ and its downstream targets".BMC infectious diseases · 2018Article
- Symptom screening for active tuberculosis in pregnant women living with HIV.The Cochrane database of systematic reviews · 2018Article
- Evaluation of the tuberculosis surveillance system in the Ashaiman municipality, in Ghana.The Pan African medical journal · 2018Article
- Effect of Pregnancy on Interferon Gamma Release Assay and Tuberculin Skin Test Detection of Latent TB Infection Among HIV-Infected Women in a High Burden Setting.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Clinical Correlates and Drug Resistance in HIV-Infected and -Uninfected Pulmonary Tuberculosis Patients in South India.World journal of AIDS · 2016Article
- Advances in Diagnostic Assays for Tuberculosis.Cold Spring Harbor perspectives in medicine · 2015Review
- Incidence and correlates of tuberculosis IGRA conversion among HIV-infected postpartum women.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2015Article
- Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses.Immunological reviews · 2015Review
- B cells and antibodies in the defense against Mycobacterium tuberculosis infection.Immunological reviews · 2015Review
- Article
- Serological diagnostic assays for HIV-associated tuberculosis in sub-Saharan Africa?Clinical and vaccine immunology : CVI · 2014Article
- Antibodies against Mycobacterial proteins as biomarkers for HIV-associated smear-negative tuberculosis.Clinical and vaccine immunology : CVI · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
One third of the world's population is estimated to be infected with Mycobacterium tuberculosis, representing a huge reservoir of potential tuberculosis (TB) disease. Risk of progression to active TB is highest in those with HIV coinfection. However, the nature of the host-pathogen relationship in those with "latent TB infection" and how this is affected by HIV coinfection are poorly understood. The traditional paradigm that distinguishes latent infection from active TB as distinct compartmentalised states is overly simplistic. Instead the host-pathogen relationship in "latent TB infection" is likely to represent a spectrum of immune responses, mycobacterial metabolic activity, and bacillary numbers. We propose that the impact of HIV infection might better be conceptualised as a shift of the spectrum towards poor immune control, higher mycobacterial metabolic activity, and greater organism load, with subsequent increased risk of progression to active disease. Here we discuss the evidence for such a model and the implications for interventions to control the HIV-associated TB epidemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.