ArticleNature genetics2010
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Registry-linked trialAbstract read
In one paragraph
Article in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03766191 (The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children), which is not on this map. Cited by 1,656 papers, 16 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,656citing papers in PubMed, 16 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children
Who cites it
1,656 citing papers in PubMed, 16 syntheses or guidelines pooled it.
- Multi-ancestry genetic architecture of heart failure subtypes.Nature communications · 2026Pooled it
- Gene-environment interplay explaining individual variation in BMI outcomes: a systematic review and meta-analysis of studies using polygenic indices.International journal of obesity (2005) · 2026Pooled it
- Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- A Systematic Review of the Effect of Gene-Lifestyle Interactions on Metabolic-Disease-Related Traits in South Asian Populations.Nutrition reviews · 2025Pooled it
- Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.The Journal of nutrition · 2024Pooled it
- Genetic Variants in the Fat Mass and Obesity-Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta-Analysis.Endocrinology, diabetes & metabolism · 2024Pooled it
- Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.International journal of obesity (2005) · 2024Pooled it
- Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.PLoS genetics · 2023Pooled it
- Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations.Journal of human genetics · 2023Pooled it
- Brain-based gene expression of putative risk genes for anorexia nervosa.Molecular psychiatry · 2023Pooled it
- GWAS-Identified Variants for Obesity Do Not Influence the Risk of Developing Multiple Myeloma: A Population-Based Study and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- The Genetic Basis of Childhood Obesity: A Systematic Review.Nutrients · 2023Pooled it
- Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis.International journal of obesity (2005) · 2023Pooled it
- Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.Human molecular genetics · 2022Pooled it
- Cross-fitted instrument: A blueprint for one-sample Mendelian randomization.PLoS computational biology · 2022Pooled it
- Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.Communications biology · 2022Pooled it
- Genetic Determinants of Steroid Responsiveness in IgA Nephropathy.Journal of the American Society of Nephrology : JASN · 2026Trial
- Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy.Open forum infectious diseases · 2025Trial
- A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings.Nature metabolism · 2024Trial
- Effect of a Novel Intervention Targeting Appetitive Traits on Body Mass Index Among Adults With Overweight or Obesity: A Randomized Clinical Trial.JAMA network open · 2022Trial
1,596 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
377 authors.
Elizabeth K SpeliotesMetabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Cristen J Willer
Sonja I Berndt
Keri L Monda
Gudmar Thorleifsson
Anne U Jackson
Hana Lango Allen
Cecilia M Lindgren
Jian'an Luan
Reedik Mägi
Joshua C Randall
Sailaja Vedantam
Thomas W Winkler
Lu Qi
Tsegaselassie Workalemahu
Iris M Heid
Valgerdur Steinthorsdottir
Heather M Stringham
Michael N Weedon
Eleanor Wheeler
Andrew R Wood
Teresa Ferreira
Robert J Weyant
Ayellet V Segrè
Karol Estrada
Liming Liang
James Nemesh
Ju-Hyun Park
Stefan Gustafsson
Tuomas O Kilpeläinen
Jian Yang
Nabila Bouatia-Naji
Tõnu Esko
Mary F Feitosa
Zoltán Kutalik
Massimo Mangino
Soumya Raychaudhuri
Andre Scherag
Albert Vernon Smith
Ryan Welch
Jing Hua Zhao
Katja K Aben
Devin M Absher
Najaf Amin
Anna L Dixon
Eva Fisher
Nicole L Glazer
Michael E Goddard
Nancy L Heard-Costa
Volker Hoesel
Jouke-Jan Hottenga
Asa Johansson
Toby Johnson
Shamika Ketkar
Claudia Lamina
Shengxu Li
Miriam F Moffatt
Richard H Myers
Narisu Narisu
John R B Perry
Marjolein J Peters
Michael Preuss
Samuli Ripatti
Fernando Rivadeneira
Camilla Sandholt
Laura J Scott
Nicholas J Timpson
Jonathan P Tyrer
Sophie van Wingerden
Richard M Watanabe
Charles C White
Fredrik Wiklund
Christina Barlassina
Daniel I Chasman
Matthew N Cooper
John-Olov Jansson
Robert W Lawrence
Niina Pellikka
Inga Prokopenko
Jianxin Shi
Elisabeth Thiering
Helene Alavere
Maria T S Alibrandi
Peter Almgren
Alice M Arnold
Thor Aspelund
Larry D Atwood
Beverley Balkau
Anthony J Balmforth
Amanda J Bennett
Yoav Ben-Shlomo
Richard N Bergman
Sven Bergmann
Heike Biebermann
Alexandra I F Blakemore
Tanja Boes
Lori L Bonnycastle
Stefan R Bornstein
Morris J Brown
Thomas A Buchanan
Fabio Busonero
Harry Campbell
Francesco P Cappuccio
Christine Cavalcanti-Proença
Yii-Der Ida Chen
Chih-Mei Chen
Peter S Chines
Robert Clarke
Lachlan Coin
John Connell
Ian N M Day
Martin den Heijer
Jubao Duan
Shah Ebrahim
Paul Elliott
Roberto Elosua
Gudny Eiriksdottir
Michael R Erdos
Johan G Eriksson
Maurizio F Facheris
Stephan B Felix
Pamela Fischer-Posovszky
Aaron R Folsom
Nele Friedrich
Nelson B Freimer
Mao Fu
Stefan Gaget
Pablo V Gejman
Eco J C Geus
Christian Gieger
Anette P Gjesing
Anuj Goel
Philippe Goyette
Harald Grallert
Jürgen Grässler
Danielle M Greenawalt
Christopher J Groves
Vilmundur Gudnason
Candace Guiducci
Anna-Liisa Hartikainen
Neelam Hassanali
Alistair S Hall
Aki S Havulinna
Caroline Hayward
Andrew C Heath
Christian Hengstenberg
Andrew A Hicks
Anke Hinney
Albert Hofman
Georg Homuth
Jennie Hui
Wilmar Igl
Carlos Iribarren
Bo Isomaa
Kevin B Jacobs
Ivonne Jarick
Elizabeth Jewell
Ulrich John
Torben Jørgensen
Pekka Jousilahti
Antti Jula
Marika Kaakinen
Eero Kajantie
Lee M Kaplan
Sekar Kathiresan
Johannes Kettunen
Leena Kinnunen
Joshua W Knowles
Ivana Kolcic
Inke R König
Seppo Koskinen
Peter Kovacs
Johanna Kuusisto
Peter Kraft
Kirsti Kvaløy
Jaana Laitinen
Olivier Lantieri
Chiara Lanzani
Lenore J Launer
Cecile Lecoeur
Terho Lehtimäki
Guillaume Lettre
Jianjun Liu
Marja-Liisa Lokki
Mattias Lorentzon
Robert N Luben
Barbara Ludwig
MAGIC
Paolo Manunta
Diana Marek
Michel Marre
Nicholas G Martin
Wendy L McArdle
Anne McCarthy
Barbara McKnight
Thomas Meitinger
Olle Melander
David Meyre
Kristian Midthjell
Grant W Montgomery
Mario A Morken
Andrew P Morris
Rosanda Mulic
Julius S Ngwa
Mari Nelis
Matt J Neville
Dale R Nyholt
Christopher J O'Donnell
Stephen O'Rahilly
Ken K Ong
Ben Oostra
Guillaume Paré
Alex N Parker
Markus Perola
Irene Pichler
Kirsi H Pietiläinen
Carl G P Platou
Ozren Polasek
Anneli Pouta
Suzanne Rafelt
Olli Raitakari
Nigel W Rayner
Martin Ridderstråle
Winfried Rief
Aimo Ruokonen
Neil R Robertson
Peter Rzehak
Veikko Salomaa
Alan R Sanders
Manjinder S Sandhu
Serena Sanna
Jouko Saramies
Markku J Savolainen
Susann Scherag
Sabine Schipf
Stefan Schreiber
Heribert Schunkert
Kaisa Silander
Juha Sinisalo
David S Siscovick
Jan H Smit
Nicole Soranzo
Ulla Sovio
Jonathan Stephens
Ida Surakka
Amy J Swift
Mari-Liis Tammesoo
Jean-Claude Tardif
Maris Teder-Laving
Tanya M Teslovich
John R Thompson
Brian Thomson
Anke Tönjes
Tiinamaija Tuomi
Joyce B J van Meurs
Gert-Jan van Ommen
Vincent Vatin
Jorma Viikari
Sophie Visvikis-Siest
Veronique Vitart
Carla I G Vogel
Benjamin F Voight
Lindsay L Waite
Henri Wallaschofski
G Bragi Walters
Elisabeth Widen
Susanna Wiegand
Sarah H Wild
Gonneke Willemsen
Daniel R Witte
Jacqueline C Witteman
Jianfeng Xu
Qunyuan Zhang
Lina Zgaga
Andreas Ziegler
Paavo Zitting
John P Beilby
I Sadaf Farooqi
Johannes Hebebrand
Heikki V Huikuri
Alan L James
Mika Kähönen
Douglas F Levinson
Fabio Macciardi
Markku S Nieminen
Claes Ohlsson
Lyle J Palmer
Paul M Ridker
Michael Stumvoll
Jacques S Beckmann
Heiner Boeing
Eric Boerwinkle
Dorret I Boomsma
Mark J Caulfield
Stephen J Chanock
Francis S Collins
L Adrienne Cupples
George Davey Smith
Jeanette Erdmann
Philippe Froguel
Henrik Grönberg
Ulf Gyllensten
Per Hall
Torben Hansen
Tamara B Harris
Andrew T Hattersley
Richard B Hayes
Joachim Heinrich
Frank B Hu
Kristian Hveem
Thomas Illig
Marjo-Riitta Jarvelin
Jaakko Kaprio
Fredrik Karpe
Kay-Tee Khaw
Lambertus A Kiemeney
Heiko Krude
Markku Laakso
Debbie A Lawlor
Andres Metspalu
Patricia B Munroe
Willem H Ouwehand
Oluf Pedersen
Brenda W Penninx
Annette Peters
Peter P Pramstaller
Thomas Quertermous
Thomas Reinehr
Aila Rissanen
Igor Rudan
Nilesh J Samani
Peter E H Schwarz
Alan R Shuldiner
Timothy D Spector
Jaakko Tuomilehto
Manuela Uda
André Uitterlinden
Timo T Valle
Martin Wabitsch
Gérard Waeber
Nicholas J Wareham
Hugh Watkins
Procardis Consortium
James F Wilson
Alan F Wright
M Carola Zillikens
Nilanjan Chatterjee
Steven A McCarroll
Shaun Purcell
Eric E Schadt
Peter M Visscher
Themistocles L Assimes
Ingrid B Borecki
Panos Deloukas
Caroline S Fox
Leif C Groop
Talin Haritunians
David J Hunter
Robert C Kaplan
Karen L Mohlke
Jeffrey R O'Connell
Leena Peltonen
David Schlessinger
David P Strachan
Cornelia M van Duijn
H-Erich Wichmann
Timothy M Frayling
Unnur Thorsteinsdottir
Gonçalo R Abecasis
Inês Barroso
Michael Boehnke
Kari Stefansson
Kari E North
Mark I McCarthy
Joel N Hirschhorn
Erik Ingelsson
Ruth J F Loos
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2MType 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MGenetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MRisk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MUniversity of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4MBritish Heart FoundationCancer Research UKChief Scientist Office CZB/4/710Department of HealthIntramural NIH HHS Z01 HG000024Medical Research Council G0000934Medical Research Council G0401527Medical Research Council G0501184Medical Research Council G0600331Medical Research Council G0600705Medical Research Council G0601261Medical Research Council G0701863Medical Research Council G0801056Medical Research Council G0900554Medical Research Council G9521010Medical Research Council G9824984Medical Research Council MC_QA137934Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_U106188470Medical Research Council MC_U127561128Medical Research Council MC_U137686857NCI NIH HHS CA047988NCI NIH HHS CA49449NCI NIH HHS CA50385NCI NIH HHS CA65725NCI NIH HHS CA67262NCI NIH HHS CA87969NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA065725NCI NIH HHS R01 CA067262NCI NIH HHS U01 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HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P30-DK072488NIDDK NIH HHS R01 DK058845NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK068336NIDDK NIH HHS R01DK068336NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK073490NIDDK NIH HHS R01-DK073490NIDDK NIH HHS R01 DK075681NIDDK NIH HHS R01DK075681NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01-DK075787NIDDK NIH HHS R56 DK062370NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK062418NIDDK NIH HHS U01-DK062418NIGMS NIH HHS U01 GM074518NIGMS NIH HHS U01-GM074518NIMH NIH HHS MH084698NIMH NIH HHS R01 MH059565NIMH NIH HHS R01 MH059566NIMH NIH HHS R01 MH059571NIMH NIH HHS R01 MH059586NIMH NIH HHS R01 MH059587NIMH NIH HHS R01 MH059588NIMH NIH HHS R01 MH060870NIMH NIH HHS R01 MH060879NIMH NIH HHS R01 MH061675NIMH NIH HHS R01 MH063706NIMH NIH HHS R01 MH067257NIMH NIH HHS R01 MH081800NIMH NIH HHS R01 MH084698NIMH NIH HHS R01-MH59160NIMH NIH HHS R01-MH59565NIMH NIH HHS R01-MH59566NIMH NIH HHS R01-MH59571NIMH NIH HHS R01-MH59586NIMH NIH HHS R01-MH59587NIMH NIH HHS R01-MH59588NIMH NIH HHS R01-MH60870NIMH NIH HHS R01-MH60879NIMH NIH HHS R01-MH61675NIMH NIH HHS R01-MH63706NIMH NIH HHS R01-MH67257NIMH NIH HHS R01-MH79469NIMH NIH HHS R01-MH79470NIMH NIH HHS R01-MH81800NIMH NIH HHS RL1 MH083268NIMH NIH HHS RL1-MH083268NIMH NIH HHS U01 MH079469NIMH NIH HHS U01 MH079470Wellcome Trust 064890Wellcome Trust 068545Wellcome Trust 072960Wellcome Trust 075491Wellcome Trust 076113Wellcome Trust 077016Wellcome Trust 079557Wellcome Trust 079895Wellcome Trust 081682Wellcome Trust 083270Wellcome Trust 085301Wellcome Trust 086596Wellcome Trust 090532
Abstract
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
Indexed as
Body Mass IndexChromosome MappingBody HeightBody SizeBody WeightGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansObesityPolymorphism, Single NucleotideWhite People
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NCT03766191ClinicalTrials.gov
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