ArticleCell cycle (Georgetown, Tex.)2010
β-Arrestin-1 links mitogenic sonic hedgehog signaling to the cell cycle exit machinery in neural precursors.
Article in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- MiR-326: Role and significance in brain cancers.Non-coding RNA research · 2025Review
- β-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum.Frontiers in cell and developmental biology · 2023Article
- CREB signaling activity correlates with differentiation and survival in medulloblastoma.Scientific reports · 2021Article
- Downregulation of miR-326 and its host gene β-arrestin1 induces pro-survival activity of E2F1 and promotes medulloblastoma growth.Molecular oncology · 2021Article
- The Role of β-Arrestins in Regulating Stem Cell Phenotypes in Normal and Tumorigenic Cells.International journal of molecular sciences · 2020Review
- An autoregulatory cell cycle timer integrates growth and specification in chick wing digit development.eLife · 2019Article
- Transcriptional repressor REST drives lineage stage-specific chromatin compaction atScience signaling · 2019Article
- β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.BMC cancer · 2017Article
- β-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and GThe Journal of biological chemistry · 2017Article
- Article
- Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.PloS one · 2016Article
- Co-expression of β-arrestin1 and NF-кB is associated with cancer progression and poor prognosis in lung adenocarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.Oncogene · 2013Article
- Article
- An essential role for p38 MAPK in cerebellar granule neuron precursor proliferation.Acta neuropathologica · 2012Article
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6 authors.
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Abstract
Development of the cerebellum, a brain region regulating posture and coordination, occurs post-natally and is marked by rapid proliferation of granule neuron precursors (CGNPs), stimulated by mitogenic Sonic hedgehog (Shh) signaling. β-Arrestin (βArr) proteins play important roles downstream of Smoothened, the Shh signal transducer. However, whether Shh regulates βArrs and what role they play in Shh-driven CGNP proliferation remains to be determined. Here, we report that Shh induces βArr1 accumulation and localization to the nucleus, where it participates in enhancing expression of the cyclin dependent kinase (cdk) inhibitor p27, whose accumulation eventually drives CGNP cell cycle exit. βArr1 knockdown enhances CGNP proliferation and reduces p27 expression. Thus, Shh-mediated βArr1 induction represents a novel negative feedback loop within the Shh mitogenic pathway, such that ongoing Shh signaling, while required for CGNPs to proliferate, also sets up a cell-intrinsic clock programming their ultimate exit from the cell cycle.
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