ReviewEpigenetics2011
Histone tyrosine phosphorylation comes of age.
Review in Epigenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription.Nature chemical biology · 2023Article
- The Expanding Constellation of Histone Post-Translational Modifications in the Epigenetic Landscape.Genes · 2021Review
- Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium.Biomolecules · 2019Review
- Livin Regulates H2A.XFrontiers in oncology · 2019Article
- Article
- Article
- Histone modifications as regulators of life and death inMicrobial cell (Graz, Austria) · 2015Review
- Intrinsically disordered proteins in the nucleus of human cells.Biochemistry and biophysics reports · 2015Article
- Histones: at the crossroads of peptide and protein chemistry.Chemical reviews · 2015Review
- A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs.Neurotoxicity research · 2015Review
- A Proteome-wide Domain-centric Perspective on Protein Phosphorylation.Molecular & cellular proteomics : MCP · 2014Article
- Disordered proteinaceous machines.Chemical reviews · 2014Review
- Pyk2 cytonuclear localization: mechanisms and regulation by serine dephosphorylation.Cellular and molecular life sciences : CMLS · 2013Article
- The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.PLoS pathogens · 2013Article
- Histone H2A variants in nucleosomes and chromatin: more or less stable?Nucleic acids research · 2012Review
- H2B Tyr37 phosphorylation suppresses expression of replication-dependent core histone genes.Nature structural & molecular biology · 2012Article
- HIstome--a relational knowledgebase of human histone proteins and histone modifying enzymes.Nucleic acids research · 2012Article
- A peek into the complex realm of histone phosphorylation.Molecular and cellular biology · 2011Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Histones were discovered over a century ago and have since been found to be the most extensively posttranslationally modified proteins, although tyrosine phosphorylation of histones had remained elusive until recently. The year 2009 proved to be a landmark year for histone tyrosine (Y) phosphorylation as five research groups independently discovered this modification. Three groups describe phosphorylation of Y142 in the variant histone H2A.X, where it may be involved in the cellular decision making process to either undergo DNA repair or apoptosis in response to DNA damage. Further, one group suggests that phosphorylation of histone H3 on Y99 is crucial for its regulated proteolysis in yeast, while another found that Y41 phosphorylation modulates chromatin architecture and oncogenesis in mammalian cells. These pioneering studies provide the initial conceptual framework for further analyses of the diverse roles of tyrosine phosphorylation on different histones, with far reaching implications for human health and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.