SynthesisOccupational and environmental medicine2011
A meta-analysis of leukaemia risk from protracted exposure to low-dose gamma radiation.
Synthesis in Occupational and environmental medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
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- Epidemiological Studies of Low-Dose Ionizing Radiation and Cancer: Summary Bias Assessment and Meta-Analysis.Journal of the National Cancer Institute. Monographs · 2020Pooled it
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- Chemotherapy and Physical Therapeutics Modulate Antigens on Cancer Cells.Frontiers in immunology · 2022Review
- Genetics of blood malignancies among Iranian population: an overview.Diagnostic pathology · 2020Review
- Burden of occupational morbidity from selected causes in the United States overall and by NORA industry sector, 2012: A conservative estimate.American journal of industrial medicine · 2019Article
- Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation.PloS one · 2014Article
- Leukaemia incidence in the Techa River Cohort: 1953-2007.British journal of cancer · 2013Article
- Chernobyl cleanup workers from Estonia: follow-up for cancer incidence and mortality.Journal of radiological protection : official journal of the Society for Radiological Protection · 2013Article
- Potential impacts of radon, terrestrial gamma and cosmic rays on childhood leukemia in France: a quantitative risk assessment.Radiation and environmental biophysics · 2013Article
- Risk of leukaemia mortality from exposure to ionising radiation in US nuclear workers: a pooled case-control study.Occupational and environmental medicine · 2013Article
- Incidence and mortality trends of leukemia and lymphoma in Croatia, 1988-2009.Croatian medical journal · 2012Article
- Multi-model inference of adult and childhood leukaemia excess relative risks based on the Japanese A-bomb survivors mortality data (1950-2000).Radiation and environmental biophysics · 2011Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextMore than 400,000 workers annually receive a measurable radiation dose and may be at increased risk of radiation-induced leukaemia. It is unclear whether leukaemia risk is elevated with protracted, low-dose exposure.
objectiveWe conducted a meta-analysis examining the relationship between protracted low-dose ionising radiation exposure and leukaemia. DATA SOURCES: Reviews by the National Academies and United Nations provided a summary of informative studies published before 2005. PubMed and Embase databases were searched for additional occupational and environmental studies published between 2005 and 2009. STUDY SELECTION: We selected 23 studies that: (1) examined the association between protracted exposures to ionising radiation and leukaemia excluding chronic lymphocytic subtype; (2) were a cohort or nested case-control design without major bias; (3) reported quantitative estimates of exposure; and (4) conducted exposure-response analyses using relative or excess RR per unit exposure.
methodsStudies were further screened to reduce information overlap. Random effects models were developed to summarise between-study variance and obtain an aggregate estimate of the excess RR at 100 mGy. Publication bias was assessed by trim and fill and Rosenthal's file drawer methods.
resultsWe found an ERR at 100 mGy of 0.19 (95% CI 0.07 to 0.32) by modelling results from 10 studies and adjusting for publication bias. Between-study variance was not evident (p=0.99).
conclusionsProtracted exposure to low-dose gamma radiation is significantly associated with leukaemia. Our estimate agreed well with the leukaemia risk observed among exposed adults in the Life Span Study (LSS) of atomic bomb survivors, providing increased confidence in the current understanding of leukaemia risk from ionising radiation. However, unlike the estimates obtained from the LSS, our model provides a precise, quantitative summary of the direct estimates of excess risk from studies of protracted radiation exposures.
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