ArticleThe Plant cell2010
Mitochondrial beta-cyanoalanine synthase is essential for root hair formation in Arabidopsis thaliana.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 143 citations in OpenAlex.
- Cyanide Metabolism in Apple Embryos During Dormancy Breakage Is Modulated by NO or HCN Application.Biology · 2026Article
- HPlant, cell & environment · 2026Article
- Metabolic Enzyme MeHNL11 Regulates MeCAS1b Transcription for Cyanide Reutilization in Response to Nitrate Deficiency in Cassava.Plant biotechnology journal · 2026Article
- Organelle-specific hydrogen sulfide metabolism governs redox homeostasis to regulate plant autophagy and cadmium stress resilience.Redox biology · 2026Article
- Article
- Comprehensive Analysis of the OASTL Gene Family in Potato (International journal of molecular sciences · 2024Article
- Amino acids biosynthesis in root hair development: a mini-review.Biochemical Society transactions · 2024Review
- Phototropin2 3'UTR overlaps with the AT5G58150 gene encoding an inactive RLK kinase.BMC plant biology · 2024Article
- New Insights on the Role of ß-Cyanoalanine Synthase CAS-C1 in Root Hair Elongation through Single-Cell Proteomics.Plants (Basel, Switzerland) · 2023Article
- Old poisons, new signaling molecules: the case of hydrogen cyanide.Journal of experimental botany · 2023Article
- Proline, Cysteine and Branched-Chain Amino Acids in Abiotic Stress Response of Land Plants and Microalgae.Plants (Basel, Switzerland) · 2023Review
- HAntioxidants & redox signaling · 2023Article
- Cyanogenesis, a Plant Defence Strategy against Herbivores.International journal of molecular sciences · 2023Review
- The role of cyanoalanine synthase and alternative oxidase in promoting salt stress tolerance in Arabidopsis thaliana.BMC plant biology · 2023Article
- Proteome Dynamics of Persulfidation in Leaf Tissue under Light/Dark Conditions and Carbon Deprivation.Antioxidants (Basel, Switzerland) · 2023Article
- Comparative proteome profiles of Polygonatum cyrtonema Hua rhizomes (Rhizoma Ploygonati) in response to different levels of cadmium stress.BMC plant biology · 2023Article
- Mitochondrial H2S donor AP39 induces stomatal closure by modulating guard cell mitochondrial activity.Plant physiology · 2023Article
- Enhancement of root sulfur metabolic pathway by overexpression ofMolecular breeding : new strategies in plant improvement · 2023Article
- Hydroxynitrile lyase defends Arabidopsis against Tetranychus urticae.Plant physiology · 2022Article
- β-Cyanoalanine synthase protects mites against Arabidopsis defenses.Plant physiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyanide is stoichiometrically produced as a coproduct of the ethylene biosynthesis pathway and is detoxified by β-cyanoalanine synthase enzymes. The molecular and phenotypical analysis of T-DNA insertion mutants of the mitochondrial β-cyanoalanine synthase CYS-C1 suggests that discrete accumulation of cyanide is not toxic for the plant and does not alter mitochondrial respiration rates but does act as a strong inhibitor of root hair development. The cys-c1 null allele is defective in root hair formation and accumulates cyanide in root tissues. The root hair defect is phenocopied in wild-type plants by the exogenous addition of cyanide to the growth medium and is reversed by the addition of hydroxocobalamin or by genetic complementation with the CYS-C1 gene. Hydroxocobalamin not only recovers the root phenotype of the mutant but also the formation of reactive oxygen species at the initial step of root hair tip growth. Transcriptional profiling of the cys-c1 mutant reveals that cyanide accumulation acts as a repressive signal for several genes encoding enzymes involved in cell wall rebuilding and the formation of the root hair tip as well as genes involved in ethylene signaling and metabolism. Our results demonstrate that mitochondrial β-cyanoalanine synthase activity is essential to maintain a low level of cyanide for proper root hair development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.