ArticleAmerican journal of respiratory and critical care medicine2011
The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study.
Article in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials.BMC pulmonary medicine · 2020Pooled it
- Persistence of atopic dermatitis (AD): A systematic review and meta-analysis.Journal of the American Academy of Dermatology · 2016Pooled it
- Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults.BMJ open · 2014Trial
- Developmentally Regulated CYP2E1 Expression Is Associated with a Fetal Pulmonary Transcriptional Response to Maternal Acetaminophen Exposure.Biomedicines · 2025Article
- A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung.American journal of respiratory cell and molecular biology · 2025Article
- Prevalence, Management, and Risk Factors of Asthma Among School-Age Children in Yogyakarta, Indonesia.Journal of asthma and allergy · 2023Article
- Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- Association of prenatal acetaminophen use and acetaminophen metabolites with DNA methylation of newborns: analysis of two consecutive generations of the Isle of Wight birth cohort.Environmental epigenetics · 2022Article
- Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?The Journal of pediatrics · 2021Review
- EA3: A softmax algorithm for evidence appraisal aggregation.PloS one · 2021Article
- Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood.JAMA psychiatry · 2020Article
- E-Synthesis: A Bayesian Framework for Causal Assessment in Pharmacosurveillance.Frontiers in pharmacology · 2019Article
- Long-term adverse effects of paracetamol - a review.British journal of clinical pharmacology · 2018Review
- Effect of Early-Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age.American journal of respiratory and critical care medicine · 2018Article
- Article
- Acetaminophen use and asthma in children.Canadian family physician Medecin de famille canadien · 2017Review
- Effects of maternal geohelminth infections on allergy in early childhood.The Journal of allergy and clinical immunology · 2016Article
- Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.Thorax · 2015Article
- Causal assessment of pharmaceutical treatments: why standards of evidence should not be the same for benefits and harms?Drug safety · 2015Article
- Recurrent wheezing is associated with intestinal protozoan infections in Warao Amerindian children in Venezuela: a cross-sectional survey.BMC infectious diseases · 2014Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
rationaleAcetaminophen has been hypothesized to increase the risk of asthma and allergic disease, and geohelminth infection to reduce the risk, but evidence from longitudinal cohort studies is lacking.
objectivesTo investigate the independent effects of these exposures on the incidence of wheeze and eczema in a birth cohort.
methodsIn 2005-2006 a population-based cohort of 1,065 pregnant women from Butajira, Ethiopia, was established, to whom 1,006 live singleton babies were born. At ages 1 and 3, questionnaire data were collected on wheeze, eczema, child's use of acetaminophen, and various potential confounders, along with a stool sample for geohelminth analysis. Those without wheeze (n = 756) or eczema (n = 780) at age 1 were analyzed to determine the independent effects of geohelminth infection and acetaminophen use in the first year of life on the incidence of wheeze and eczema by age 3. MEASUREMENTS AND MAIN
resultsWheeze and eczema incidence between the ages of 1 and 3 were reported in 7.7% (58 of 756) and 7.3% (57 of 780) of children, respectively. Acetaminophen use was significantly associated with a dose-dependent increased risk of incident wheeze (adjusted odds ratio = 1.88 and 95% confidence interval 1.03-3.44 for one to three tablets and 7.25 and 2.02-25.95 for ≥ 4 tablets in the past month at age 1 vs. never), but not eczema. Geohelminth infection was insufficiently prevalent (<4%) to compute estimates of effect.
conclusionsThese findings suggest frequent acetaminophen use early in life increases the risk of new-onset wheeze, whereas the role of geohelminth infection on allergic disease incidence remains to be seen as the cohort matures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.