ArticleGenes & development2010
Notch dimerization is required for leukemogenesis and T-cell development.
Article in Genes & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Dimerization-dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors.The FEBS journal · 2026Article
- Single-molecule tweezers decode hidden dimerization patterns of membrane proteins within lipid bilayers.Nature communications · 2025Article
- NOTCH1 dimeric signaling is essential for T-cell leukemogenesis and leukemia maintenance.Blood · 2025Article
- The cellular Notch1 protein promotes KSHV reactivation in an Rta-dependent manner.Journal of virology · 2024Article
- Comprehensive genomic features indicative for Notch responsiveness.Nucleic acids research · 2024Article
- Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability.Nature communications · 2024Article
- Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force.Nature communications · 2024Article
- Notch intracellular domains form transcriptionally active heterodimeric complexes on sequence-paired sites.Scientific reports · 2024Article
- Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.Science immunology · 2023Article
- The integrative analysis based on super-enhancer related genes for predicting different subtypes and prognosis of patient with lower-grade glioma.Frontiers in genetics · 2023Article
- FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.Science advances · 2022Article
- Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor.PLoS genetics · 2021Article
- MYC in T-cell acute lymphoblastic leukemia: functional implications and targeted strategies.Blood science (Baltimore, Md.) · 2021Review
- Biophysics of Notch Signaling.Annual review of biophysics · 2021Review
- Inaccessible LCG Promoters Act as Safeguards to Restrict T Cell Development to Appropriate Notch Signaling Environments.Stem cell reports · 2021Article
- Genome-Wide Analysis IdentifiesFrontiers in cell and developmental biology · 2021Article
- Article
- Pharmacological disruption of the Notch transcription factor complex.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- MYC degradation via AURKB inhibition: a new brake in the path to T-ALL.Blood science (Baltimore, Md.) · 2020Article
- Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis.Cancer cell · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Notch signaling regulates myriad cellular functions by activating transcription, yet how Notch selectively activates different transcriptional targets is poorly understood. The core Notch transcriptional activation complex can bind DNA as a monomer, but it can also dimerize on DNA-binding sites that are properly oriented and spaced. However, the significance of Notch dimerization is unknown. Here, we show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor. The varying requirements for Notch dimerization result from the differential sensitivity of specific Notch target genes. In particular, c-Myc and pre-T-cell antigen receptor α (Ptcra) are dimerization-dependent targets, whereas Hey1 and CD25 are not. These findings identify functionally important differences in the responsiveness among Notch target genes attributable to the formation of higher-order complexes. Consequently, it may be possible to develop a new class of Notch inhibitors that selectively block outcomes that depend on Notch dimerization (e.g., leukemogenesis).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.