ReviewCurrent opinion in genetics & development2010
Multiscale complexity in the mammalian circadian clock.
Review in Current opinion in genetics & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Plasticity manifolds and degeneracy govern circadian oscillations of neuronal intrinsic properties in the suprachiasmatic nucleus.iScience · 2023Article
- Systems Level Understanding of Circadian Integration with Cell Physiology.Journal of molecular biology · 2020Review
- Understanding Quantitative Circadian Regulations Are Crucial Towards Advancing Chronotherapy.Cells · 2019Review
- Sleep Modelling across Physiological Levels.Clocks & sleep · 2019Review
- Interventions to Minimize Jet Lag After Westward and Eastward Flight.Frontiers in physiology · 2019Article
- Design Principles of Phosphorylation-Dependent Timekeeping in Eukaryotic Circadian Clocks.Cold Spring Harbor perspectives in biology · 2018Review
- Protein sequestration versus Hill-type repression in circadian clock models.IET systems biology · 2016Review
- Melatonin signaling and its modulation of PfNF-YB transcription factor expression in Plasmodium falciparum.International journal of molecular sciences · 2013Review
- Chronobiology of Melatonin beyond the Feedback to the Suprachiasmatic Nucleus-Consequences to Melatonin Dysfunction.International journal of molecular sciences · 2013Article
- Suppressed cellular oscillations in after-hours mutant mice are associated with enhanced circadian phase-resetting.The Journal of physiology · 2013Article
- A mechanism for robust circadian timekeeping via stoichiometric balance.Molecular systems biology · 2012Article
- Weakly circadian cells improve resynchrony.PLoS computational biology · 2012Article
- Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators.Trends in neurosciences · 2011Review
- Genetics of circadian rhythms in Mammalian model organisms.Advances in genetics · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The field of systems biology studies how the interactions among individual components (e.g. genes and proteins) yield interesting and complex behavior. The circadian (daily) timekeeping system in mammals is an ideal system to study complexity because of its many biological scales (from genes to animal behavior). A wealth of data at each of these scales has recently been discovered. Within each scale, modeling can advance our understanding of challenging problems that arise in studying mammalian timekeeping. However, future work must focus on bridging the multiple spatial and temporal scales in the modeling of SCN network. Here we review recent advances, and then delve into a few areas that are promising research directions. We also discuss the flavor of modeling needed (simple or detailed) as well as new techniques that are needed to meet the challenges in modeling data across scales.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.