ReviewSeminars in cancer biology2010
Lethal mutagenesis: targeting the mutator phenotype in cancer.
Review in Seminars in cancer biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Error-induced extinction in a multi-type critical birth-death process.Journal of mathematical biology · 2024Article
- Review
- Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.PLoS genetics · 2021Article
- Can we use epigenetics to prime chemoresistant lymphomas?Hematology. American Society of Hematology. Education Program · 2020Review
- Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology.Journal of Cancer · 2020Review
- Viral quasispecies.PLoS genetics · 2019Article
- Review
- Adaptive dynamics of unstable cancer populations: The canonical equation.Evolutionary applications · 2018Article
- High mutation rates limit evolutionary adaptation in Escherichia coli.PLoS genetics · 2018Article
- Noise-induced bistability in the fate of cancer phenotypic quasispecies: a bit-strings approach.Scientific reports · 2018Article
- Review
- Abrupt transitions to tumor extinction: a phenotypic quasispecies model.Journal of mathematical biology · 2017Article
- A population genetics perspective on the determinants of intra-tumor heterogeneity.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Significant Prognostic Features and Patterns of SomaticCancer informatics · 2017Article
- The rich phase structure of a mutator model.Scientific reports · 2016Article
- The influence of subclonal resistance mutations on targeted cancer therapy.Nature reviews. Clinical oncology · 2016Review
- Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences.Cancer research · 2016Article
- New strategies against drug resistance to herpes simplex virus.International journal of oral science · 2016Review
- Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer.Genome medicine · 2016Article
- The study of homology between tumor progression genes and members of retroviridae as a tool to predict target-directed therapy failure.Frontiers in pharmacology · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The evolution of cancer and RNA viruses share many similarities. Both exploit high levels of genotypic diversity to enable extensive phenotypic plasticity and thereby facilitate rapid adaptation. In order to accumulate large numbers of mutations, we have proposed that cancers express a mutator phenotype. Similar to cancer cells, many viral populations, by replicating their genomes with low fidelity, carry a substantial mutational load. As high levels of mutation are potentially deleterious, the viral mutation frequency is thresholded at a level below which viral populations equilibrate in a traditional mutation-selection balance, and above which the population is no longer viable, i.e., the population undergoes an error catastrophe. Because their mutation frequencies are fine-tuned just below this error threshold, viral populations are susceptible to further increases in mutational load and, recently this phenomenon has been exploited therapeutically by a concept that has been termed lethal mutagenesis. Here we review the application of lethal mutagenesis to the treatment of HIV and discuss how lethal mutagenesis may represent a novel therapeutic approach for the treatment of solid cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.