Evidence map›Paper›PMID 20934320›Full record

ReviewCurrent opinion in neurobiology2010

Cell death and sexual differentiation of behavior: worms, flies, and mammals.

Nancy G Forger, Geert J de Vries

Open access · greenAbstract readComparative StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Androgenic regulation of sexually dimorphic expression of RNA binding motif protein 48 in the developing mouse cortex and hippocampus.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019
    Article
  2. Article
  3. Hypothalamic control of the male neonatal testosterone surge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Review
  4. Review
  5. Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Article
  6. Article
  7. Review
  8. Sex determination strategies in 2012: towards a common regulatory model?Reproductive biology and endocrinology : RB&E · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nancy G ForgerDepartment of Psychology and Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA. nforger@psych.umass.edu
Geert J de Vries
University of Massachusetts Amherst · US

Funding

The Neural Basis of Sexually Dimorphic Brain FunctionR01MH047538 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI DE VRIES, GEERT J. · 1991 to 2013
$3.2M
Cell Death and Neural Sex DifferencesR01MH068482 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI FORGER, NANCY G · 2004 to 2013
$2.9M
Sexual Differentiation of the Nervous SystemK02MH072825 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI FORGER, NANCY G · 2005 to 2009
$626k
NIMH NIH HHS K02 MH072825NIMH NIH HHS R01 MH047538NIMH NIH HHS R01-MH047538NIMH NIH HHS R01 MH068482NIMH NIH HHS R01-MH068482
6 · The paper itself

Abstract

Sex differences in the nervous system are found throughout the animal kingdom. Here, we discuss three prominent genetic models: nematodes, fruit flies, and mice. In all three, differential cell death is central to sexual differentiation and shared molecular mechanisms have been identified. Our knowledge of the precise function of neural sex differences lags behind. One fruitful approach to the 'function' question is to contrast sexual differentiation in standard laboratory animals with differentiation in species exhibiting unique social and reproductive organizations. Advanced genetic strategies are also addressing this question in worms and flies, and may soon be applicable to vertebrates.

Indexed as

Sex CharacteristicsAnimalsCaenorhabditis elegansCell DeathDipteraDrosophilaMammalsMiceNeuronsRatsSexual Behavior, AnimalSpecies Specificity

Identifiers

PMID20934320
PMCPMC3025078
OpenAlexW2081219793

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.