ArticleNeuroscience2010
A1 receptors self-regulate adenosine release in the striatum: evidence of autoreceptor characteristics.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Dynamic and Rapid Detection of Guanosine during Ischemia.ACS chemical neuroscience · 2023Article
- Opioid-Induced Reductions in Amygdala Lateral Paracapsular GABA Neuron Circuit Activity.International journal of molecular sciences · 2023Article
- Spontaneous Adenosine and Dopamine Cotransmission in the Caudate-Putamen Is Regulated by Adenosine Receptors.ACS chemical neuroscience · 2021Article
- Spontaneous, transient adenosine release is not enhanced in the CA1 region of hippocampus during severe ischemia models.Journal of neurochemistry · 2021Article
- AACS chemical neuroscience · 2020Article
- A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats.Current pharmaceutical design · 2020Article
- Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder.Current pharmaceutical design · 2020Review
- Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats.Frontiers in pharmacology · 2019Article
- Regional Variations of Spontaneous, Transient Adenosine Release in Brain Slices.ACS chemical neuroscience · 2018Article
- Correlation of transient adenosine release and oxygen changes in the caudate-putamen.Journal of neurochemistry · 2017Article
- The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2016Article
- Real time adenosine fluctuations detected with fast-scan cyclic voltammetry in the rat striatum and motor cortex.Journal of neuroscience methods · 2015Article
- Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism.Pharmacology research & perspectives · 2015Article
- Adenosine transiently modulates stimulated dopamine release in the caudate-putamen via A1 receptors.Journal of neurochemistry · 2015Article
- Fast-scan Cyclic Voltammetry for the Characterization of Rapid Adenosine Release.Computational and structural biotechnology journal · 2015Review
- Mechanical stimulation evokes rapid increases in extracellular adenosine concentration in the prefrontal cortex.Journal of neurochemistry · 2014Article
- Presynaptic adenosine A₁ receptors modulate excitatory transmission in the rat basolateral amygdala.Neuropharmacology · 2014Article
- Characterization of spontaneous, transient adenosine release in the caudate-putamen and prefrontal cortex.PloS one · 2014Article
- The mechanism of electrically stimulated adenosine release varies by brain region.Purinergic signalling · 2013Article
- Dopamine measurement during prolonged deep brain stimulation: a proof-of-principle study of paired pulse voltammetry.Biomedical engineering letters · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adenosine A(1) receptors are inhibitory G-protein coupled receptors that presynaptically regulate neurotransmitter release, but their role in self-regulating adenosine release is not known. In this study, we examined the modulation of evoked adenosine and dopamine efflux by A(1) receptors and studied whether D(1) receptors mediate these effects. Fast-scan cyclic voltammetry at carbon-fiber microelectrodes was used for the simultaneous detection of adenosine and dopamine efflux on a subsecond time scale. Short electrical stimulation trains delivered to the substantia nigra (60 pulses, 60 Hz) were used to evoke dopamine and adenosine release in the striatum. The adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA, 1 mg/kg, i.p.) decreased both adenosine and dopamine efflux, although the effect for adenosine occurred more quickly than for dopamine. The A(1) antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX, 6 mg/kg, i.p.) increased stimulated adenosine release. The effects of CPA were partially attenuated by the dopamine D(1) receptor antagonist SCH-23390. Thus, A(1) and D(1) receptors have a synergistic interaction that modulates both stimulated adenosine and dopamine. The decrease in adenosine is not a downstream effect of lowered dopamine release, as decreasing dopamine synthesis and release with α-methyl-p-tyrosine or increasing release with haloperidol had no effect on adenosine release. This study shows that A(1) receptors have some characteristics of an autoreceptor, including self-regulation of adenosine release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.